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Fig. S1. No cytotoxicity was detected in cells treated with 12-O-tetradecanoylphorbol-13-acetate (TPA) and 7,12-dimethylbenz[a]anthracene (DMBA).

Fig. S2. Selection of human long interspersed nucleotide element-1–enhanced green fluorescent protein (hL1-EGFP) mouse strains suitable for carcinogenesis experiments.

Fig. S3. Southern blot analysis of copy numbers of transgenes in #4 and #67 in mice carrying human long interspersed nucleotide element-1 and enhanced green fluorescent protein (hL1-EGFP).

Fig. S4. Long interspersed nucleotide element-1 retrotransposition (L1-RTP) in nevi. Eight nevi samples were analyzed by PCR-based assay.

Fig. S5. Forced expression of constitutively activated form of Stat3 did not induce long interspersed nucleotide element-1 retrotransposition (L1-RTP).

Fig. S6. Forced expression of activated H-ras did not phosphorylate Stat3.

Fig. S7. Aryl hydrocarbon receptor (AhR) is required for long interspersed nucleotide element-1 retrotransposition (L1-RTP) by genotoxic carcinogens.

Fig. S8. No apparent abnormality of Gsta4 gene in tumors induced by 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate (DMBA/TPA).

Table S1. Nucleotide sequences of siRNAs targeting aryl hydrocarbon receptor (AhR) and AhR nuclear translocator 1 (ARNT1).

Table S2. Quantitative PCR of copy numbers of transgene in #4 and #67 in mice carrying human long interspersed nucleotide element-1 and enhanced green fluorescent protein (L1-EGFP).

Data S1. Full details of experimental methods used in this work.

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