Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis
Version of Record online: 22 SEP 2011
© 2011 Japanese Cancer Association
Volume 102, Issue 11, pages 2007–2013, November 2011
How to Cite
Wang, F., Osawa, T., Tsuchida, R., Yuasa, Y. and Shibuya, M. (2011), Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis. Cancer Science, 102: 2007–2013. doi: 10.1111/j.1349-7006.2011.02065.x
- Issue online: 23 OCT 2011
- Version of Record online: 22 SEP 2011
- Accepted manuscript online: 16 AUG 2011 09:12AM EST
- (Received March 31, 2011/Revised July 29, 2011/Accepted August 5, 2011/Accepted manuscript online August 16, 2011/Article first published online September 22, 2011)
Fig. S1. The duration of the silencing effect on RACK1 expression by specific RNAi.
Fig. S2. Downregulation of RACK1 markedly inhibited colony formation of HeLa and A673 cells.
Fig. S3. RACK1 knockdown significantly suppressed the invasive ability of HeLa and A673 cells.
Fig. S4. Inhibition of the invasion of HeLa and A673 cells by RACK1 silencing was not due to the suppression of cell growth.
Fig. S5. Effect of RACK1 silencing on Akt and MAPK phosphorylation from 0 to 60 h in vitro.
Fig. S6. Effect of RACK1 silencing on VEGF-B and FGF2 expression from 0 to 60 h in vitro.
Fig. S7. Representative image of xenograft tumors on Day 2 after transplantation.
Table S1. Sequences of specific primers used for angiogenic factors and RACK1.
|CAS_2065_sm_FigS1-7-TableS1.pdf||14549K||Supporting info item|
Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.