Insulin-like growth factor II mRNA-binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma
Version of Record online: 17 OCT 2011
© 2011 Japanese Cancer Association
Volume 102, Issue 12, pages 2191–2198, December 2011
How to Cite
Chen, S.-T., Jeng, Y.-M., Chang, C.-C., Chang, H.-H., Huang, M.-C., Juan, H.-F., Hsu, C.-H., Lee, H., Liao, Y.-F., Lee, Y.-L., Hsu, W.-M. and Lai, H.-S. (2011), Insulin-like growth factor II mRNA-binding protein 3 expression predicts unfavorable prognosis in patients with neuroblastoma. Cancer Science, 102: 2191–2198. doi: 10.1111/j.1349-7006.2011.02100.x
- Issue online: 20 NOV 2011
- Version of Record online: 17 OCT 2011
- Accepted manuscript online: 14 SEP 2011 06:34PM EST
- (Received January 12, 2011/Revised June 10, 2011; August 26, 2011/Accepted September 5, 2011/Accepted manuscript online September 14, 2011)
Fig. S1. Positive control of IMP3 immunohistochemical staining in gastric adenocarcinoma. Brown color denotes positive staining. Original magnification, ×200.
Fig. S2. (A) SK-N-SH neuroblastoma cells showing neurite extension after treatment with all-trans retinoic acid (RA) for 3 days. (B) IMP3 protein expression levels in SK-N-SH cells, a MYCN non-amplified cell line, decreased after cell differentiation induced by RA. (C) IMP3 protein expression levels in SK-N-SH cells decreased after IMP3 knockdown by shIMP3-1 or shIMP3-2, resulting in inhibited cell migration. *P < 0.05.
Fig. S3. Apoptotic cell death increased in SK-N-DZ neuroblastoma cells after IMP3 knockdown by shIMP3-1 or shIMP3-2. *P < 0.05.
Table S1. Differentially expressed genes in neuroblastoma tumor tissues evaluated by oligonucleotide microarray according to patient outcome.
Data S1. Supplementary materials and methods.
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