Fig. S1. The half-life of K-Ras is shortened by p16 re-expression in Capan-1 cells.

Fig. S2. K-Ras activity was significantly reduced in Capan-1 cells after transfection of human K-rasV12 antisense oligonucleotides.

Fig. S3. K-Ras and p16 seem to interact directly.

Fig. S4. p16 inhibits K-Ras activity in MiaPaCa-2 pancreatic cancer cells.

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