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Behavior of seeds and soil in the mechanism of metastasis: A deeper understanding


To whom correspondence should be addressed.

E-mail: lucy.mathot@igp.uu.se


The so-called “seed and soil” hypothesis proposed by Stephen Paget in 1889 to explain the metastatic behavior of cancer cells and the homing of certain cancers to “selected” sites has been a well-recognized phenomenon for over a century. What advances have been made to increase our understanding of this phenomenon and what does it really implicate in terms of targets for therapy? (Cancer Sci 2012; 103: 626–631)