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Original Article

Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner

  1. Takahiro Osawa1,2,
  2. Noritaka Ohga1,
  3. Yasuhiro Hida3,
  4. Kazuko Kitayama1,
  5. Kosuke Akiyama1,
  6. Yuichiro Onodera4,
  7. Manabu Fujie5,
  8. Nobuo Shinohara2,
  9. Masanobu Shindoh4,
  10. Katsuya Nonomura2,
  11. Kyoko Hida1,*

Article first published online: 17 APR 2012

DOI: 10.1111/j.1349-7006.2012.02261.x

Issue

Cancer Science

Cancer Science

Volume 103, Issue 6, pages 1038–1044, June 2012

Additional Information

How to Cite

Osawa, T., Ohga, N., Hida, Y., Kitayama, K., Akiyama, K., Onodera, Y., Fujie, M., Shinohara, N., Shindoh, M., Nonomura, K. and Hida, K. (2012), Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner. Cancer Science, 103: 1038–1044. doi: 10.1111/j.1349-7006.2012.02261.x

Author Information

  1. 1

    Department of Vascular Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan

  2. 2

    Departments of Urology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

  3. 3

    Cardiovascular and Thoracic Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

  4. 4

    Department of Oral Pathology and Biology, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan

  5. 5

    DNA Sequencing Center Section, Okinawa Institute of Science and Technology Promotion Corporation, Onna, Okinawa, Japan

*To whom correspondence should be addressed. E-mail: khida@den.hokudai.ac.jp

Publication History

  1. Issue published online: 1 JUN 2012
  2. Article first published online: 17 APR 2012
  3. Accepted manuscript online: 1 MAR 2012 05:19PM EST
  4. Manuscript Accepted: 24 FEB 2012
  5. Manuscript Revised: 17 FEB 2012
  6. Manuscript Received: 9 DEC 2011

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FilenameFormatSizeDescription
cas2261-sup-0001-fS1.epsimage/eps1876KFig. S1. Migration of mouse tumor endothelial cells (melanoma endothelial cells [EC] and renal cell carcinoma EC) was inhibited by indomethacin.
cas2261-sup-0002-fS2.epsimage/eps1852KFig. S2. PGI2 synthesis in mouse tumor endothelial cells was significantly inhibited by NS-398.
cas2261-sup-0003-fS3.epsimage/eps1747KFig. S3. RO1138452 suppressed mTEC migration by an inhibitory effect on the prostacyclin receptor (IP receptor).
cas2261-sup-0004-fS4.epsimage/eps1547KFig. S4. Tube formation of mouse tumor endothelial cells was inhibited by indomethacin.
cas2261-sup-0005-fS5.epsimage/eps1670KFig. S5. RO1138452 suppressed mouse tumor endothelial cell tube formation by an inhibitory effect on the prostacyclin receptor (IP receptor).

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