cas2294-sup-0001-figureS1.docWord document141K Fig. S1. Effects of arecoline on p21 and p27 in OCSS cells with different cell confluence.
cas2294-sup-0002-figureS2.docWord document5851K Fig. S2. Inhibition of mTORC1 activity by arecoline.
cas2294-sup-0003-figureS3.docWord document356K Fig. S3. (A) Rapamycin (10 nM) was sufficient to downregulate levels of p21 and p27. (B) Relative transcription levels of p21 and p27 after 0.5 mM arecoline treatment for 24 h.
cas2294-sup-0004-figureS4.docWord document237K Fig. S4. Independence of PI3K-Akt signaling on arecoline-mediated mTORC1 inhibition.
cas2294-sup-0005-figureS5.docWord document196K Fig. S5. Independence of AMP-activated protein kinase (AMPK) signaling on arecoline-induced downregulation of p21 and p27 in oral squamous cell carcinoma cells.
cas2294-sup-0006-figureS6.docWord document7376K Fig. S6. Strong inhibition of mTOR complex 1 (mTORC1) activities by arecoline rather than by areca nut extract (ANE).

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