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Original Article

PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter

  1. Jun-Jiang Chen1,2,
  2. Yue-Li Sun1,3,
  3. Amit K. Tiwari1,
  4. Zhi-Jie Xiao1,
  5. Kamlesh Sodani1,
  6. Dong-Hua Yang4,
  7. Saraubh G. Vispute1,
  8. Wen-Qi Jiang3,
  9. Si-Dong Chen2,*,
  10. Zhe-Sheng Chen1,*

Article first published online: 6 JUL 2012

DOI: 10.1111/j.1349-7006.2012.02328.x

Issue

Cancer Science

Cancer Science

Volume 103, Issue 8, pages 1531–1537, August 2012

Additional Information

How to Cite

Chen, J.-J., Sun, Y.-L., Tiwari, A. K., Xiao, Z.-J., Sodani, K., Yang, D.-H., Vispute, S. G., Jiang, W.-Q., Chen, S.-D. and Chen, Z.-S. (2012), PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Science, 103: 1531–1537. doi: 10.1111/j.1349-7006.2012.02328.x

Author Information

  1. 1

    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York, USA

  2. 2

    Guangdong Key Laboratory for Molecular Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China

  3. 3

    Department of Medical Oncology, Cancer Center, Sun Yat-Sen University, Guangzhou, China

  4. 4

    Biosample Repository, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

* To whom correspondence should be addressed.
E-mails: sdchen2@126.com; chenz@stjohns.edu

Publication History

  1. Issue published online: 26 JUL 2012
  2. Article first published online: 6 JUL 2012
  3. Accepted manuscript online: 11 MAY 2012 10:35AM EST
  4. Manuscript Accepted: 23 APR 2012
  5. Manuscript Revised: 21 APR 2012
  6. Manuscript Received: 23 JAN 2012

Funded by

  • National Institutes of Health. Grant Number: 1R15CA143701

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cas2328-sup-0001-Figure-S1.docxWord document1011KFig. S1. Survival curves of HEK293–pcDNA3.1 and HEK/multidrug resistance protein 7 (MRP7) at different concentrations of (A) sildenafil, (B) vardenafil and (C) tadalafil. Cell survival was determined by MTT assay, as described in the 'Materials and Methods'. Data points represent the means ± SD of triplicate determinations. Experiments were performed at least three independent times.

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