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cas2363-sup-0001-FigureS1-S7.pdfapplication/PDF231KFig. S1. IC50 values of erlotinib and gefitinib in PC-9 and PC-9/ER3, 4 and 5 cells determined by MTT assay. Fig. S2. MET gene copy number relative to GAPDH in PC-9 and PC-9/ER1, 2, 3, 4 and 5 cells. Fig. S3. Protein expression in PC-9 and PC-9/ER3, 4 and 5 cells treated with or without erlotinib for 6 h. Fig. S4. Target protein expression in PC-9 and PC-9/ER3 cells treated with each indicated concentrations of LY294002 or Stattic. Fig. S5. Growth inhibition ratio after treatment with erlotinib plus JSI-124 of PC-9/ER5 cells. Fig. S6. The combination of erlotinib with inhibition of JAK2 using siRNA in PC-9/ER3 cells suppressed pAkt in PC-9/ER3 cells. Fig. S7. Inhibition of JAK2 suppresses c-MYC expression.

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