Supported in pan by USPHS grant R01 DA07120-01A2 to H. D. Abraham.
Adverse consequences of lysergic acid diethylamide
Article first published online: 24 JAN 2006
Volume 88, Issue 10, pages 1327–1334, October 1993
How to Cite
ABRAHAM, H. D. and ALDRIDGE, A. M. (1993), Adverse consequences of lysergic acid diethylamide. Addiction, 88: 1327–1334. doi: 10.1111/j.1360-0443.1993.tb02018.x
- Issue published online: 24 JAN 2006
- Article first published online: 24 JAN 2006
The continued endemic use of hallucinogenic drugs, and of LSD in particular, raises concern regarding their short and long term adverse consequences. The epidemiology of LSD abuse is reviewed suggesting an increase in LSD use among the young as the prevalence rates for other substances continues to fall. Evidence supports the association of LSD use with panic reactions, prolonged schizoaffective psychoses and post–hallucinogen perceptual disorder, the latter being present continually for as long as 5 years. Evidence does not support claims of genetic disorders arising from hallucinogens. In light of the foregoing, current data confirm earlier findings of long lasting psychopathology arising in vulnerable individuals from the use of LSD. A hypothetical long term molecular mechanism of adverse effects is proposed.