Assessing the relationship between maternal cocaine use and abruptio placentae
Article first published online: 24 JAN 2006
Volume 92, Issue 11, pages 1547–1551, November 1997
How to Cite
HULSE, G. K., MILNE, E., ENGLISH, D. R. and HOLMAN, C. D. J. (1997), Assessing the relationship between maternal cocaine use and abruptio placentae. Addiction, 92: 1547–1551. doi: 10.1111/j.1360-0443.1997.tb02874.x
- Issue published online: 24 JAN 2006
- Article first published online: 24 JAN 2006
- Submitted 22nd March 1996; initial review completed 4th July 1996; final version accepted 12th November 1996.
Abruptio placentae during pregnancy can result in significant morbidity and mortality to both mother and infant. A comprehensive literature search of publications from 1966 to April 1995 identified 11 studies on the association between maternal cocaine use and abruptio placentae. Their results were combined in a meta-analysis. The pooled odds ratio for abruptio placentae and maternal cocaine use was 3.92 (95% confidence interval 2.77-5.46). The strength and consistency of the association, its biological plausibility and the results of experimental studies in animals all suggest that cocaine use during pregnancy causes abruptio placentae.