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Cost and cost-effectiveness of standard methadone maintenance treatment compared to enriched 180-day methadone detoxification


Carmen L. Masson
Department of Psychiatry
San Francisco General Hospital
1001 Potrero Avenue
Bldg 20, Suite 2100
San Francisco
CA 94110
Tel: (415) 206 8404


Aims  To compare the cost and cost-effectiveness of methadone maintenance treatment and 180-day methadone detoxification enriched with psychosocial services.

Design  Randomized controlled study conducted from May 1995 to April 1999.

Setting  Research clinic in an established drug treatment program.

Participants  One hundred and seventy-nine adults with diagnosed opioid dependence.

Intervention  Patients were randomized to methadone maintenance (n = 91), which required monthly 1 hour/week of psychosocial therapy during the first 6 months or 180-day detoxification (n = 88), which required 3 hours/week of psychosocial therapy and 14 education sessions during the first 6 months.

Measurements  Total health-care costs and self-reported injection drug use. A two-state Markov model was used to estimate quality-adjusted years of survival.

Findings  Methadone maintenance produced significantly greater reductions in illicit opioid use than 180-day detoxification during the last 6 months of treatment. Total health-care costs were greater for maintenance than detoxification treatment ($7564 versus $6687; P < 0.001). Although study costs were significantly higher for methadone maintenance than detoxification patients ($4739 versus $2855, P < 0.001), detoxification patients incurred significantly higher costs for substance abuse and mental health care received outside the study. Methadone maintenance may provide a modest survival advantage compared with detoxification. The cost per life-year gained is $16 967. Sensitivity analysis revealed a cost-effectiveness ratio of less than $20 000 per quality-adjusted life-year over a wide range of modeling assumptions.

Conclusions  Compared with enriched detoxification services, methadone maintenance is more effective than enriched detoxification services with a cost-effectiveness ratio within the range of many accepted medical interventions and may provide a survival advantage. Results provide additional support for the use of sustained methadone therapy as opposed to detoxification for treating opioid addiction.