Take-home naloxone to reduce heroin death

Authors

  • Catherine T. Baca,

    Corresponding author
    1. Center on Alcoholism, Substance Abuse, and Addictions (CASAA) and Family and Community Medicine, University of New Mexico, Albuquerque, New Mexico
      Catherine T. Baca
      160 Washington SE ♯ 62
      Albuquerque
      NM 87108
      USA
      E-mail: baca5@unm.edu
    Search for more papers by this author
  • Kenneth J. Grant

    1. Center on Alcoholism, Substance Abuse, and Addictions (CASAA) and Family and Community Medicine, University of New Mexico, Albuquerque, New Mexico
    Search for more papers by this author

Catherine T. Baca
160 Washington SE ♯ 62
Albuquerque
NM 87108
USA
E-mail: baca5@unm.edu

ABSTRACT

Background  This paper reviews the relevant literature related to the distribution of take-home naloxone.

Methods  A Medline search was conducted on articles published between January 1990 and June 2004 to identify scientific literature relevant to this subject. Those publications were reviewed, and from them other literature was identified and reviewed.

Results  The prevalence, pathophysiology and circumstances of heroin overdose, and also bystander response are included in this review. Naloxone peer distribution has been instituted to varying degrees in the United States, Italy, Spain, Germany and the United Kingdom.

Conclusion  At this point the evidence supporting naloxone distribution is primarily anecdotal, although promising. Although the distribution of naloxone holds promise for further reducing heroin overdose mortality, problems remain. Naloxone alone may be insufficient in some cases to revive the victim, and cardiopulmonary resuscitation (CPR), especially rescue breathing, may also be needed. A second dose of naloxone might be necessary. Complications following resuscitation from overdose may infrequently need in-hospital care. Mortality from injecting without anyone else present will be unaffected by take-home naloxone. Take-home naloxone should be studied in a rigorous scientific manner.

Ancillary