J. Aron and M. P. Paulus declare no conflict of interests.
Location, location: using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use
Article first published online: 27 FEB 2007
Volume 102, Issue Supplement s1, pages 33–43, April 2007
How to Cite
Aron, J. L. and Paulus, M. P. (2007), Location, location: using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use. Addiction, 102: 33–43. doi: 10.1111/j.1360-0443.2006.01778.x
- Issue published online: 27 FEB 2007
- Article first published online: 27 FEB 2007
- Anterior cingulate;
- functional magnetic resonance imaging;
- prefrontal cortex
Aims The purpose of this review is to summarize the neural substrate dysfunctions and disrupted cognitive, affective and experiential processes observed in methamphetamine and cocaine-dependent individuals.
Methods We reviewed all publications in PubMed that conducted comparison studies between healthy volunteers and cocaine-, amphetamine- or methamphetamine-dependent individuals using functional magnetic resonance imaging.
Results Stimulant dependence is characterized by a distributed alteration of functional activation to a number of experimental paradigms. Attenuated anterior and posterior cingulate activation, reduced inferior frontal and dorsolateral prefrontal cortex activation and altered posterior parietal activation point towards an inadequate demand-specific processing of information. Processes reported most consistently to be deficient in these functional neuroimaging studies include inhibitory control, executive functioning and decision-making.
Conclusion One emerging theme is that stimulant-dependent individuals show specific, rather than generic, brain activation differences, i.e. instead of showing more or less brain activation regardless of task, they exhibit process-related brain activation differences that are consistent with a shift from context-specific, effortful processing to more stereotyped, habitual response generation.