Effect of add-on gabapentin on opioid withdrawal symptoms in opium-dependent patients
Article first published online: 7 AUG 2008
© 2008 The Authors. Journal compilation © 2008 Society for the Study of Addiction
Volume 103, Issue 9, pages 1495–1499, September 2008
How to Cite
Kheirabadi, G. R., Ranjkesh, M., Maracy, M. R. and Salehi, M. (2008), Effect of add-on gabapentin on opioid withdrawal symptoms in opium-dependent patients. Addiction, 103: 1495–1499. doi: 10.1111/j.1360-0443.2008.02248.x
- Issue published online: 7 AUG 2008
- Article first published online: 7 AUG 2008
- Submitted 25 October 2007; initial review completed 23 January 2008; final version accepted 2 April 2008
Vol. 104, Issue 10, 1776, Article first published online: 8 SEP 2009
- opium dependence;
- opioid withdrawal;
- withdrawal symptoms
Aims Evaluation of the efficacy of gabapentin in patients undergoing out-patient treatment for opiate withdrawal.
Design A 3-week double-blind, randomized, placebo-controlled trial of adjunctive gabapentin in methadone-assisted detoxification (MAD).
Setting Specialized Addictive Behaviors Unit, an out-patient unit for the treatment of patients with an addictive disorder serving the city of Isfahan (Iran).
Participants Forty out-patients, 37 males and three females, aged 21–61 years, who met DSM-IV criteria for opiate dependence.
Intervention Random assignment of subjects to receive adjunctive treatment with either gabapentin (900 mg/day) or placebo under double-blind conditions.
Measurements Severity of subjective withdrawal symptoms using the Subjective Opiate Withdrawal Scale at six stages.
Findings Despite the superiority of gabapentin on controlling some of withdrawal symptoms, no significant differences were reported between two groups.
Conclusions Dosage of 900 mg/day of gabapentin is not significantly superior to placebo in controlling opiate withdrawal symptoms.