Hospitalizations for opioid poisoning: a nation-wide population-based study in Denmark, 1998–2004
Article first published online: 12 DEC 2008
© 2009 The Authors. Journal compilation © 2009 Society for the Study of Addiction
Volume 104, Issue 1, pages 104–108, January 2009
How to Cite
Bjørn, A.-M. B., Jepsen, P., Larsson, H. J., Thomsen, H. F., Kieler, H., Ehrenstein, V. and Christensen, S. (2009), Hospitalizations for opioid poisoning: a nation-wide population-based study in Denmark, 1998–2004. Addiction, 104: 104–108. doi: 10.1111/j.1360-0443.2008.02420.x
- Issue published online: 12 DEC 2008
- Article first published online: 12 DEC 2008
- Submitted 14 February 2008; initial review completed 12 May 2008; final version accepted 8 October 2008
- hospitalization rates;
- strong analgesics
Aims To assess hospitalization rates (HR) for poisoning with heroin, methadone or strong analgesics and relate them to quantities of prescribed methadone and strong analgesics in Denmark between 1998 and 2004.
Design Population-based ecological study.
Settings We extracted data on all emergency department visits and hospital admissions registered in the Danish National Patient Registry with a diagnosis of poisoning with heroin (n = 1688), methadone (n = 173) or strong analgesics (n = 384). To ascertain sale of prescribed medications we used data from the Danish Medicines Agency.
Measurements Age- and gender-standardized HR and defined daily doses (DDD) per 1000 people per day.
Findings HR for heroin poisoning was 4.4 [95% confidence interval (CI): 3.8–4.9] per 100 000 person-years (p-y) in 1998 and 4.6 (CI: 4.0–5.2) per 100 000 p-y in 2004. HR for methadone poisoning increased from 0.1 (CI: 0.0–0.2) per 100 000 p-y in 1998 to 1.1 (CI: 0.8–1.4) per 100 000 p-y in 2004. HR for poisoning with strong analgesics increased from 0.6 (CI: 0.4–0.9) per 100 000 p-y in 1998 to 2.1 (CI: 1.8–2.6) per 100 000 p-y in 2004. The sale of prescribed strong analgesics (5.0 DDD per 1000 people per day in 1998 to 5.9 DDD in 2004) and methadone (3.0 DDD per 1000 people per day in 1998 to 3.4 DDD in 2004) increased slightly between 1998 and 2004.
Conclusion Increasing sale of prescribed methadone and strong analgesics coincided with increasing HRs of poisoning with these drugs, whereas HR of heroin poisoning varied. Further longitudinal studies are important for the guidance of future policy making.