This work was conducted at the New York State Psychiatric Institute, Department of Clinical Therapeutics, Smoking Cessation Clinic, New York, NY.
Depressive mood, suicide ideation and anxiety in smokers who do and smokers who do not manage to stop smoking after a target quit day
Article first published online: 15 SEP 2010
© 2010 The Authors, Addiction © 2010 Society for the Study of Addiction
Volume 105, Issue 12, pages 2209–2216, December 2010
How to Cite
Berlin, I., Chen, H. and Covey, L. S. (2010), Depressive mood, suicide ideation and anxiety in smokers who do and smokers who do not manage to stop smoking after a target quit day. Addiction, 105: 2209–2216. doi: 10.1111/j.1360-0443.2010.03109.x
- Issue published online: 3 NOV 2010
- Article first published online: 15 SEP 2010
- Submitted 12 November 2009; initial review completed 19 January 2010; final version accepted 21 June 2010
- depressive mood;
- history of major depression;
- quit day;
- smoking abstinence;
- suicide ideation;
- treatment seeking smokers
Aims The effect of successful and unsuccessful smoking cessation on depressive mood, anxiety- and suicide-related outcomes is unclear. The aim of this secondary analysis was to explore the relationship between abstinence status and these outcomes.
Design Cohort of adult smokers attempting to stop smoking. Smoking status was assessed by a daily diary; depressed mood, anxiety and suicidal tendencies by the Hamilton Depression Rating Scale (HDRS). The association of complete and point-prevalence abstinence with the HDRS variables was assessed using multi-level linear regression models.
Setting Randomized trial of sertraline versus placebo for smoking cessation with weekly behavioural support provided in a clinic.
Participants A total of 133 adult smokers with past major depression.
Findings Pre-quit mood scores did not predict smoking status post-quit day. Both continuous and point-prevalence abstainers had significantly lower total HDRS, suicide and anxiety scores, adjusted for all potential confounders, during the period following quit day than did non-abstainers who experienced a significant mood deterioration. There was a significant effect of sertraline on post-quit HDRS scores but not on abstinence.
Conclusions Contrary to expectation, smoking abstinence among smokers with a history of major depression did not lead to increase in depression, anxiety or suicide ideation; however, failed quit attempts did. Persisting with a quit attempt while unable to achieve abstinence may be associated with mood deterioration.