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Figure S1 Pooled estimates (derived from random effects meta-analysis) of region-specific all-cause crude mortality rates. See Table 1 for details of individual studies comprising each regional total. Crude mortality rates (CMR) rounded to two decimal places

Figure S2 All-cause mortality according to sex

Figure S3 Relative risk of mortality [all-cause crude mortality rates (CMR) and non-AIDS-related CMR], according to HIV status at baseline (HIV-positive/HIV-negative)

Table S1 Included studies investigating all-cause mortality associated with dependent opioid use, published 1990–2008

Table S2 Cohorts reporting proportion of deaths due to AIDS, overdose, suicide and traumatic causes of death (percentages)

Table S3 Comparison of out-of-treatment versus in-treatment crude mortality rates (CMR)

Table S4 Univariate and multivariable associations between study-level variables and all-cause crude mortality rates (CMR) and standardized mortality ratios (SMR)

Appendix SA Search strings for literature searches

Appendix SB Number of articles identified from opioid mortality search combinations

Appendix SC Excluded cohort studies/papers from short list, and reason for exclusion

Appendix SD Access database manual and data entry rules

Appendix SE Quality Index variables

Appendix SF Data derived and calculation methodsAppendix G—Global Burden of Disease country and region list

Appendix SH Included studies investigating all-cause mortality associated with dependent opioid use, published 1990–2008

Appendix SI Crude mortality rates and standardized mortality ratios separated by age

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