• Adolescent;
  • anti-inflammatory agents;
  • benzydamine;
  • Brazil;
  • cross-sectional studies;
  • epidemiology;
  • hallucinogens;
  • non prescription drugs;
  • students

Benzydamine hydrochloride is a nonsteroidal anti-inflammatory drug, with medical indication for disorders of the oral and vaginal mucosa [1]. It is available in a number of countries and in different pharmaceuticals preparations, such as pills, vaginal douche preparations, mouthwash, dermal cream and aerosol [2]. In Brazil, it can be purchased for less than US$ 5 a unit.

One of the few case reports on the recreational use of this substance was a 22 year-old male who discovered information on the web about its hallucinogenic properties and decided to experiment. The subject described a state of hyperactivity, excitation, visual hallucinations and muscle weakness [3].

Last year our research group published an article describing the use of benzydamine for recreational purposes by 78 children and adolescents in street situation in a national survey in Brazil [4]. They described a dosage use ranged from 100 to 2000 mg of benzydamine; most reports were of use of an oral preparation acquired through a drugstore without a medical prescription. Some of them reported that they had associated this drug with another substance, commonly an alcoholic beverage, in an attempt to enhance its psychotropic effects.

Recently we also identified the benzydamine recreational use among 2.3% of a sample of 5208 students of Sao Paulo, the largest city of Brazil. The sample was composed of 12 to 18 year-old students from private schools, with the main characteristic of belonging to the wealthiest socioeconomic status of the country. Most of the cases were high school students, and no differences were found between gender. The students that reported misuse of benzydamine reported more lifetime use of alcohol, tobacco, marijuana and inhalants (P < 0.01). However, there were fewer users of ecstasy and medications without prescriptions, like benzodiazepines and amphetamines.

By accessing a series of social web networks in Brazil, it is easy to perceive how widespread the knowledge is on recreational use of benzydamine. Information is shared on what quantity is necessary to achieve the desired hedonistic effect, the combined use with other drugs to potentiate its effect and even opinions that encourage or discourage its use [5].

This letter serves as an alert to other countries on drawing attention to a cheap substance, readily available and with growing information about its misuse and the potential to be abused by children and adolescents.

Conflict of interest declaration

  1. Top of page
  2. Conflict of interest declaration
  3. References



  1. Top of page
  2. Conflict of interest declaration
  3. References
  • 1
    Quane P. A., Graham G. G., Ziegler J. B. Pharmacology of benzydamine. Inflammopharmacology 1998; 6: 95107.
  • 2
    Gomez-Lopez L., Hernandez-Rodriguez J., Pou J., Nogue S. Acute overdose due to benzydamine. Hum Exp Toxicol 1999; 18: 4713.
  • 3
    Anand J. S., Glebocka M. L., Korolkiewicz R. P. Recreational abuse with benzydamine hydrochloride (tantum rosa). Clin Toxicol (Phila) 2007; 45: 1989.
  • 4
    Opaleye E. S., Noto A. R., Sanchez Z. M., Moura Y. G., Galduróz J. C., Carlini E. A. Recreational use of benzydamine as a hallucinogen among street youth in Brazil. Rev Bras Psiquiatr 2009; 31: 20813.
  • 5
    Souza J. F., Marinho C. L., Guilam M. C. [Medicine consumption and the internet: critical evaluation of a virtual community]. Rev Assoc Med Bras 2008; 54: 22531.