Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence
Article first published online: 23 DEC 2010
© 2010 The Authors, Addiction © 2010 Society for the Study of Addiction
Volume 106, Issue 4, pages 739–748, April 2011
How to Cite
Sobczyk-Kopciol, A., Broda, G., Wojnar, M., Kurjata, P., Jakubczyk, A., Klimkiewicz, A. and Ploski, R. (2011), Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence. Addiction, 106: 739–748. doi: 10.1111/j.1360-0443.2010.03248.x
- Issue published online: 3 MAR 2011
- Article first published online: 23 DEC 2010
- Accepted manuscript online: 21 OCT 2010 07:45AM EST
- Submitted 29 June 2010; initial review completed 23 August 2010; final version accepted 12 October 2010
Aims To investigate whether the FTO rs9939609 A allele (a risk factor for obesity) is associated with measures of alcohol consumption.
Design Population-based cross-sectional study and two case–control studies.
Setting Poland and the Warsaw area.
Participants A total of 6584 subjects from the WOBASZ survey and two cohorts of alcohol-dependent patients (n = 145 and n = 148).
Measurements Questionnaire data analysis, rs9939609 typing.
Findings Among individuals drinking alcohol, the obesity-associated AA genotype was also associated with lower total ethanol consumption [sex-, age- and body mass index (BMI)-adjusted difference: 0.21 g/day, P = 0.012] and distinct drinking habits with relatively low frequency of drinks but larger volume consumed at a time as evidenced by (i) association between AA and frequency/amount of typical drinks (P = 0.023, multiple logistic regression analysis); (ii) inverse correlation between AA and drink frequency adjusted for drink size (P = 0.007 for distilled spirits, P = 0.018 for beer); (iii) decreased frequency of AA [odds ratio (OR) = 0.46, P = 0.0004] among those who drank small amounts of distilled spirits (≤100 ml at a time) but frequently (≥1–2 times/week). A decrease of AA was also found in both cohorts of alcohol-dependent patients versus geographically matched subjects from WOBASZ yielding a pooled estimate of OR = 0.59, confidence interval (CI): 0.40–0.88, P = 0.008. Exploratory analysis showed that those with rs9939609 AA reported lower (by 1.22) mean number of cigarettes/day during a year of most intense smoking (P = 0.003) and were older at start of smoking by 0.44 years (P = 0.016).
Conclusions The FTO AA genotype, independently from its effect on BMI, is associated with measures of ethanol consumption and possibly tobacco smoking.