Former affiliation: Center for Drug Use and HIV Research, National Development and Research Institutes, New York City, NY, USA.
Predictors and correlates of reduced frequency or cessation of injection drug use during a randomized HIV prevention intervention trial
Article first published online: 23 DEC 2010
© 2010 The Authors, Addiction © 2010 Society for the Study of Addiction
Volume 106, Issue 3, pages 601–608, March 2011
How to Cite
Mackesy-Amiti, M. E., Ouellet, L. J., Golub, E. T., Hudson, S., Hagan, H. and Garfein, R. S. (2011), Predictors and correlates of reduced frequency or cessation of injection drug use during a randomized HIV prevention intervention trial. Addiction, 106: 601–608. doi: 10.1111/j.1360-0443.2010.03251.x
- Issue published online: 7 FEB 2011
- Article first published online: 23 DEC 2010
- Accepted manuscript online: 26 OCT 2010 03:07AM EST
- Submitted 18 June 2010; initial review completed 20 August 2010; final version accepted 13 October 2010
- HIV prevention;
- injection cessation;
- injection drug use;
- randomized controlled trial
Aims This study conducted a secondary analysis to examine injection cessation and decreasing frequency of injection during a multi-site randomized controlled HIV prevention intervention trial that sought to reduce sexual and injection risk behavior among young injection drug users.
Design and Setting A six-session, cognitive–behavioral skills-building intervention in which participants were taught peer education skills [peer education intervention (PEI)] was compared with a time-equivalent attention control. Follow-up interviews were conducted at 3 and 6 months post-baseline.
Participants Trial participants were HIV and hepatitis C virus (HCV) antibody-negative injection drug users aged 15–30 years. Participants who had at least one follow-up interview and reported injecting drugs in the previous 3 months at baseline were eligible for the present analysis (n = 690).
Measurements At each interview, data were collected on the number of times participants injected drugs over the previous 3 months.
Findings Twenty-seven per cent of participants reported at least one 3-month period of injection cessation. In a multivariate, zero-inflated negative binomial regression adjusting for prior injection frequency, time of follow-up and psychosocial variables, PEI trial arm and smaller session size were associated significantly with injection cessation. Trial arm had no effect on the frequency of injection among those who continued to inject.
Conclusions HIV prevention interventions that encourage injection drug users to take on the role of peer educator may have the additional benefit of increasing the likelihood of injection cessation. Intervention group size is also an important consideration, with smaller groups having higher rates of cessation.