Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs
Version of Record online: 15 FEB 2011
© 2010 The Authors, Addiction © 2010 Society for the Study of Addiction
Volume 106, Issue 4, pages 777–786, April 2011
How to Cite
Halpern, J. H., Sherwood, A. R., Hudson, J. I., Gruber, S., Kozin, D. and Pope Jr, H. G. (2011), Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. Addiction, 106: 777–786. doi: 10.1111/j.1360-0443.2010.03252.x
- Issue online: 3 MAR 2011
- Version of Record online: 15 FEB 2011
- Accepted manuscript online: 26 OCT 2010 03:07AM EST
- Submitted 12 July 2010; initial review completed 31 August 2010; final version accepted 13 October 2010
- Cognitive function;
- substance abuse
Aims In field studies assessing cognitive function in illicit ecstasy users, there are several frequent confounding factors that might plausibly bias the findings toward an overestimate of ecstasy-induced neurocognitive toxicity. We designed an investigation seeking to minimize these possible sources of bias.
Design We compared illicit ecstasy users and non-users while (1) excluding individuals with significant life-time exposure to other illicit drugs or alcohol; (2) requiring that all participants be members of the ‘rave’ subculture; and (3) testing all participants with breath, urine and hair samples at the time of evaluation to exclude possible surreptitious substance use. We compared groups with adjustment for age, gender, race/ethnicity, family-of-origin variables and childhood history of conduct disorder and attention deficit hyperactivity disorder. We provide significance levels without correction for multiple comparisons.
Setting Field study.
Participants Fifty-two illicit ecstasy users and 59 non-users, aged 18–45 years.
Measurements Battery of 15 neuropsychological tests tapping a range of cognitive functions.
Findings We found little evidence of decreased cognitive performance in ecstasy users, save for poorer strategic self-regulation, possibly reflecting increased impulsivity. However, this finding might have reflected a pre-morbid attribute of ecstasy users, rather than a residual neurotoxic effect of the drug.
Conclusions In a study designed to minimize limitations found in many prior investigations, we failed to demonstrate marked residual cognitive effects in ecstasy users. This finding contrasts with many previous findings—including our own—and emphasizes the need for continued caution in interpreting field studies of cognitive function in illicit ecstasy users.