Order of authors amended after online publication, 3rd August 2011; John Marsden is the senior author on this paper.
Mephedrone: use, subjective effects and health risks
Version of Record online: 27 JUL 2011
© 2011 The Authors, Addiction © 2011 Society for the Study of Addiction
Volume 106, Issue 11, pages 1991–1996, November 2011
How to Cite
Winstock, A., Mitcheson, L., Ramsey, J., Davies, S., Puchnarewicz, M. and Marsden, J. (2011), Mephedrone: use, subjective effects and health risks. Addiction, 106: 1991–1996. doi: 10.1111/j.1360-0443.2011.03502.x
- Issue online: 6 OCT 2011
- Version of Record online: 27 JUL 2011
- Accepted manuscript online: 18 MAY 2011 05:50AM EST
- Submitted 20 February 2011; initial review completed 13 April 2011; final version accepted 9 May 2011
- legal highs;
Aims To assess the patterns of use, subjective effect profile and dependence liability of mephedrone, supported by corroborative urine toxicology.
Design Cross-sectional structured telephone interview.
Setting UK-based drug users associated with the dance music scene.
Participants A total of 100 mephedrone users, recruited through their involvement with the dance music scene.
Measurements Assessment of pattern of use, acute and after effects, DSM dependence criteria and gas chromatography-mass spectrometry urinalysis.
Findings Mephedrone consumption results in typical stimulant-related subjective effects: euphoria, increased concentration, talkativeness, urge to move, empathy, jaw clenching, reduced appetite and insomnia. Thirty per cent of the sample potentially met criteria for DSM-IV dependence and there was evidence of a strong compulsion to use the drug (47% had used the drug for 2 or more consecutive days). Self-reported recent consumption of mephedrone was confirmed by toxicological analysis in all of the 14 participants who submitted a urine sample.
Conclusion Mephedrone has a high abuse and health risk liability, with increased tolerance, impaired control and a compulsion to use, the predominant reported dependence symptoms.