Compulsive use of dopamine replacement therapy: a model for stimulant drug addiction?

Authors

  • Polly Ambermoon,

    1. The University of Queensland, UQ Centre for Clinical Research, Queensland, Australia,
    Search for more papers by this author
  • Adrian Carter,

    1. The University of Queensland, UQ Centre for Clinical Research, Queensland, Australia,
    2. The University of Melbourne, School of Psychological Sciences, Victoria, Australia,
    Search for more papers by this author
  • Wayne Hall,

    Corresponding author
    1. The University of Queensland, UQ Centre for Clinical Research, Queensland, Australia,
    2. The University of Queensland, Queensland Brain Institute, Queensland, Australia,
    Search for more papers by this author
  • Nadeeka Dissanayaka,

    1. The University of Queensland, UQ Centre for Clinical Research, Queensland, Australia,
    2. Neurology Research Centre, Royal Brisbane and Womens' Hospital, Herston, Queensland, Australia
    Search for more papers by this author
  • John O'Sullivan

    1. Neurology Research Centre, Royal Brisbane and Womens' Hospital, Herston, Queensland, Australia
    2. Royal Brisbane Clinical School, School of Medicine, The University of Queensland, Queensland, Australia
    Search for more papers by this author

Wayne Hall, The University of Queensland, UQ Centre for Clinical Research, Royal Brisbane and Women's Hospital Site, Qld 4029, Australia. E-mail: w.hall@uq.edu.au

ABSTRACT

The compulsive use of dopamine replacement therapy (DRT) or dopamine dysregulation syndrome (DDS) is one of the behavioural disturbances reported in some patients with Parkinson's disease (PD) and other disorders who are receiving DRT. We draw this phenomenon to the attention of the addiction field as a topic deserving of more systematic study. We outline: the clinical features, epidemiology and clinical correlates of the disorder; the unresolved issues in its definition and diagnosis; and its potential relevance to neurobiological models of psychostimulant addiction. We argue that compulsive DRT use may provide a useful model for drug addiction, while advancing our understanding of the neurobiology of addiction and improving the management of PD patients with the disorder.

Ancillary