Compulsive use of dopamine replacement therapy: a model for stimulant drug addiction?
Article first published online: 27 JUL 2011
© 2011 The Authors, Addiction © 2011 Society for the Study of Addiction
Volume 107, Issue 2, pages 241–247, February 2012
How to Cite
Ambermoon, P., Carter, A., Hall, W., Dissanayaka, N. and O'Sullivan, J. (2012), Compulsive use of dopamine replacement therapy: a model for stimulant drug addiction?. Addiction, 107: 241–247. doi: 10.1111/j.1360-0443.2011.03511.x
- Issue published online: 17 JAN 2012
- Article first published online: 27 JUL 2011
- Submitted 25 January 2011; initial review completed 9 March 2011; final version accepted 18 May 2011
- dopamine dysregulation syndrome;
- dopamine replacement therapy;
- impulse control disorders;
- Parkinson's disease;
The compulsive use of dopamine replacement therapy (DRT) or dopamine dysregulation syndrome (DDS) is one of the behavioural disturbances reported in some patients with Parkinson's disease (PD) and other disorders who are receiving DRT. We draw this phenomenon to the attention of the addiction field as a topic deserving of more systematic study. We outline: the clinical features, epidemiology and clinical correlates of the disorder; the unresolved issues in its definition and diagnosis; and its potential relevance to neurobiological models of psychostimulant addiction. We argue that compulsive DRT use may provide a useful model for drug addiction, while advancing our understanding of the neurobiology of addiction and improving the management of PD patients with the disorder.