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Co-occurrence of obsessive-compulsive disorder and substance use disorder in the general population

Authors

  • Rianne M. Blom,

    1. Department of Psychiatry, Academical Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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  • Maarten Koeter,

    1. Department of Psychiatry, Academical Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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  • Wim van den Brink,

    1. Department of Psychiatry, Academical Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
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  • Ron de Graaf,

    1. Netherlands Institute of Mental Health and Addiction, Utrecht, the Netherlands
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  • Margreet ten Have,

    1. Netherlands Institute of Mental Health and Addiction, Utrecht, the Netherlands
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  • Damiaan Denys

    Corresponding author
    1. Department of Psychiatry, Academical Medical Centre, University of Amsterdam, Amsterdam, the Netherlands
    2. the Netherlands Institute for Neuroscience, an Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, the Netherlands
      Damiaan Denys, Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA.2-179, PO Box 75867, 1070 AW Amsterdam, the Netherlands. E-mail: ddenys@gmail.com
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Damiaan Denys, Department of Psychiatry, Academic Medical Center, University of Amsterdam, PA.2-179, PO Box 75867, 1070 AW Amsterdam, the Netherlands. E-mail: ddenys@gmail.com

ABSTRACT

Aim  Very little is known about the relationship between obsessive–compulsive disorder (OCD) and substance use disorder (SUD). The aim of this study is to compare the co-occurrence of OCD with SUD to the co-occurrence of SUD with other psychiatric disorders in a representative community sample.

Design  In order to examine the association of SUD and OCD, logistic regression analyses were used generating odds ratios and 95% confidence intervals for life-time prevalence and 12-month prevalence.

Setting and participants  Cross-sectional data were derived from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), a large representative sample of the Dutch population (n = 7076).

Measurements  The Composite International Diagnostic Interview (CIDI) 1.1 was used to assess Diagnostic and Statistical Manual of Mental Disorders Axis I criteria for psychiatric disorders.

Findings  The life-time and 12-month odds of being diagnosed with SUD in subjects with OCD are significantly higher than the odds of SUD for people without a psychiatric disorder. In men, the co-occurrence of substance dependence and OCD is significantly higher than the co-occurrence of substance dependence and other psychiatric disorders, whereas in women this co-occurrence does not differ significantly.

Conclusions  The co-occurrence of substance dependence in obsessive–compulsive disorder is higher than the co-occurrence of substance dependence in other non-obsessive–compulsive disorder DSM disorders, especially in men.

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