Cannabis use and cognitive function: 8-year trajectory in a young adult cohort

Authors

  • Robert J. Tait,

    Corresponding author
    1. Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia
      Robert Tait, Centre for Mental Health Research, College of Medicine and Health Science, Building 63, Eggleston Road, Australian National University, Canberra, ACT 0200, Australia. E-mail: robert.tait@anu.edu.au
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  • Andrew Mackinnon,

    1. Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia
    2. Centre for Youth Mental Health (Orygen Research Centre), The University of Melbourne Melbourne, VIC, Australia
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  • Helen Christensen

    1. Centre for Mental Health Research, Australian National University, Canberra, ACT, Australia
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Robert Tait, Centre for Mental Health Research, College of Medicine and Health Science, Building 63, Eggleston Road, Australian National University, Canberra, ACT 0200, Australia. E-mail: robert.tait@anu.edu.au

ABSTRACT

Aim  To evaluate the relationship between change in cannabis use and changed cognitive performance over 8 years.

Design  We used survey methodology with a cohort design.

Setting and participants  An Australian community sample aged 20–24 years at baseline.

Measures  We assessed cognitive performance with the California Verbal Learning Test (CVLT) (immediate and delayed), Spot-the-Word test (STW), Symbol Digit Modality test (SDMT) and Digit Backwards (DB). Groups of cannabis users were defined from self-reports across three waves as: ‘never’ (n= 420) ‘remain light’ (n= 71), ‘former light’ (n= 231), ‘remain heavy’ (n= 60), ‘former heavy’ (n= 60) and ‘always former’ (since start of study) (n= 657). Planned contrasts within mixed model repeated-measures analysis of variance was used for longitudinal analysis with an adjusted alpha of 0.01.

Findings  Data were obtained from 2404 participants with 1978 (82.3%) completing wave 3. At baseline there were significant differences between cannabis groups on CVLT (immediate and delayed) and SDMT. However, after controlling for education, gender, gender × group and gender × wave, there were no significant between-group differences and only CVLT immediate recall reached adjusted statistically significant longitudinal change associated with changed cannabis use (group × wave P= 0.007). Specifically, former heavy users improved their performance relative to remaining heavy users (estimated marginal means: former heavy 6.1–7.5: remain heavy 6.4–6.6).

Conclusions  Cessation of cannabis use appears to be associated with an improvement in capacity for recall of information that has just been learned. No other measures of cognitive performance were related to cannabis after controlling for confounds.

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