Topiramate for the treatment of methamphetamine addiction: a multi-center placebo-controlled trial
Version of Record online: 28 FEB 2012
© 2011 The Authors, Addiction © 2011 Society for the Study of Addiction
Volume 107, Issue 7, pages 1297–1306, July 2012
How to Cite
Elkashef, A., Kahn, R., Yu, E., Iturriaga, E., Li, S.-H., Anderson, A., Chiang, N., Ait-Daoud, N., Weiss, D., McSherry, F., Serpi, T., Rawson, R., Hrymoc, M., Weis, D., McCann, M., Pham, T., Stock, C., Dickinson, R., Campbell, J., Gorodetzky, C., Haning, W., Carlton, B., Mawhinney, J., Li, M. D. and Johnson, B. A. (2012), Topiramate for the treatment of methamphetamine addiction: a multi-center placebo-controlled trial. Addiction, 107: 1297–1306. doi: 10.1111/j.1360-0443.2011.03771.x
- Issue online: 6 JUN 2012
- Version of Record online: 28 FEB 2012
- Accepted manuscript online: 16 DEC 2011 09:41AM EST
- Submitted 21 October 2010; initial review completed 30 December 2010; final version accepted 9 December 2011
- Abstinence facilitation;
- methamphetamine abuse;
Aims Topiramate has shown efficacy at facilitating abstinence from alcohol and cocaine abuse. This double-blind, placebo-controlled out-patient trial tested topiramate for treating methamphetamine addiction.
Design Participants (n = 140) were randomized to receive topiramate or placebo (13 weeks) in escalating doses from 50 mg/day to the target maintenance of 200 mg/day in weeks 6–12 (tapered in week 13). Medication was combined with weekly brief behavioral compliance enhancement treatment.
Setting The trial was conducted at eight medical centers in the United States.
Participants One hundred and forty methamphetamine-dependent adults took part in the trial.
Measurements The primary outcome was abstinence from methamphetamine during weeks 6–12. Secondary outcomes included use reduction versus baseline, as well as psychosocial variables.
Findings In the intent-to-treat analysis, topiramate did not increase abstinence from methamphetamine during weeks 6–12. For secondary outcomes, topiramate reduced weekly median urine methamphetamine levels and observer-rated severity of dependence scores significantly. Subjects with negative urine before randomization (n = 26) had significantly greater abstinence on topiramate versus placebo during study weeks 6–12. Topiramate was safe and well tolerated.
Conclusions Topiramate does not appear to promote abstinence in methamphetamine users but can reduce the amount taken and reduce relapse rates in those who are already abstinent.