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Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain)

  1. Xavier Muñoz1,2,
  2. Pilar Amiano3,4,5,
  3. David Celorrio6,
  4. Miren Dorronsoro3,4,5,
  5. María-José Sánchez5,7,
  6. José M. Huerta5,8,
  7. Aurelio Barricarte5,9,
  8. Larraitz Arriola3,4,5,
  9. Carmen Navarro5,8,
  10. Esther Molina-Montes5,7,
  11. M. Dolores Chirlaque5,8,
  12. Eva Ardanaz5,9,
  13. Laudina Rodriguez10,
  14. Eric J. Duell2,
  15. Elizabeth Hijona11,12,
  16. Marta Herreros-Villanueva11,12,
  17. Núria Sala1,2,
  18. Luis Bujanda5,11,12,*

Article first published online: 20 AUG 2012

DOI: 10.1111/j.1360-0443.2012.03970.x

Issue

Addiction

Addiction

Volume 107, Issue 12, pages 2117–2127, December 2012

Additional Information

How to Cite

Muñoz, X., Amiano, P., Celorrio, D., Dorronsoro, M., Sánchez, M.-J., Huerta, J. M., Barricarte, A., Arriola, L., Navarro, C., Molina-Montes, E., Chirlaque, M. D., Ardanaz, E., Rodriguez, L., Duell, E. J., Hijona, E., Herreros-Villanueva, M., Sala, N. and Bujanda, L. (2012), Association of alcohol dehydrogenase polymorphisms and life-style factors with excessive alcohol intake within the Spanish population (EPIC-Spain). Addiction, 107: 2117–2127. doi: 10.1111/j.1360-0443.2012.03970.x

Author Information

  1. 1

    Molecular Epidemiology Group, Translational Research Laboratory, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain

  2. 2

    Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain

  3. 3

    Public Health Division of Gipuzkoa, Department of Health of the regional Government of the Basque Country, San Sebastian, Spain

  4. 4

    BIODonostia Research Institute, San Sebastián, Spain

  5. 5

    CIBER Epidemiología y Salud Pública CIBERESP, Madrid, Spain

  6. 6

    BIOMICs Research Group, ‘Lucio Lascaray’ Centre for Research and Advanced Studies (CIEA), University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain

  7. 7

    Andalusian School of Public Health, Granada, Spain

  8. 8

    Department of Epidemiology, Murcia Health Council, Murcia, Spain

  9. 9

    Public Health Institute of Navarra, Pamplona, Spain

  10. 10

    Public Health and Participation Directorate, Asturias, Spain

  11. 11

    Colorectal Cancer Multidisciplinary Unit, Donostia Hospital, University of the Basque Country, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), San Sebastian, Spain

  12. 12

    Department of Gastroenterology, Donostia Hospital, BIODonostia Research Institute University of the Basque Country (UPV/EHU), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), San Sebastian, Spain

* Correspondence to: Luis Bujanda, Colorectal Cancer Multidisciplinary Unit, Donostia Hospital, University of the Basque Country, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), San Sebastian 20014, Spain. E-mail: luis.bujanda@osakidetza.net; Pilar Amiano, Public Health Division of Gipuzkoa, Research Institute BIODonostia, Basque Region, San Sebastián 20010, Spain. E-mail: epicss-san@ej-gv.es

Publication History

  1. Issue published online: 20 NOV 2012
  2. Article first published online: 20 AUG 2012
  3. Accepted manuscript online: 12 JUN 2012 06:31AM EST
  4. Manuscript Accepted: 29 MAY 2012
  5. Manuscript Revised: 20 MAR 2012
  6. Manuscript Received: 8 FEB 2012

Funded by

  • Spanish Ministry of Health and Consumer Affairs
  • Carlos III Health Institute (ISCIII). Grant Number: 2007-047O

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Keywords:

  • ADH6 ;
  • ADH1B ;
  • excessive alcohol intake;
  • genetic susceptibility;
  • life-style factors;
  • polymorphisms

Abstract

Aims

To analyse associations between alcohol dehydrogenase (ADH) polymorphisms and alcohol intake in Spanish men and women.

Design and settings

We analysed the relationship between 21 genetic variants in ADH genes and excessive alcohol intake in both men and women. Single nucleotide polymorphisms (SNPs) were genotyped using a customized array and a sex-stratified analysis was performed.

Measurements

Ethanol intake was calculated using a validated dietary history questionnaire.

Participants

Heavy consumers of alcohol (≥70 g/day in men, ≥42 g/day in women) (653 cases) and very low or non-consumers (<2 g/day) (880 controls) from the Spanish cohort of the European Prospective Investigation into Cancer (EPIC).

Findings

We found statistically significant associations between alcohol intake and known life-style factors; namely, smoking and food energy intake (meat and fruit/seeds) in both men and women, as well as with physical activity in women and educational level in men. Additionally, we found that a non-synonymous coding SNP in ADH1B (rs1229984) is associated inversely with excessive alcohol intake in men [odds ratio (OR) = 0.19, 95% confidence interval (CI) = 0.11–0.33; P = 4.77E−10) and women (OR = 0.48, 95% CI = 0.27–0.83; P = 0.0067). Furthermore, ADH6 rs3857224 was found associated with heavy alcohol intake in women (OR = 1.61, 95% CI = 1.21–2.14; P = 1.01E−3), but not in men.

Conclusions

In the Spanish population, the single nucleotide polymorphism of alcohol dehydrogenase ADH1B, rs1229984, is associated inversely with alcohol intake in both men and women. Another polymorphism of ADH6, rs3857224, is associated with heavy alcohol intake in women.

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