The influence of isolated doses of drugs, feeding and colonic bacterial ureolysis on urea breath test results
Version of Record online: 31 MAR 2007
Alimentary Pharmacology & Therapeutics
Volume 9, Issue 6, pages 705–709, December 1995
How to Cite
PERRI, F., MAES, B., GEYPENS, B., GHOOS, Y., HIELE, M. and RUTGEERTS, P. (1995), The influence of isolated doses of drugs, feeding and colonic bacterial ureolysis on urea breath test results. Alimentary Pharmacology & Therapeutics, 9: 705–709. doi: 10.1111/j.1365-2036.1995.tb00442.x
- Issue online: 31 MAR 2007
- Version of Record online: 31 MAR 2007
- Accepted for publication 14 July 1995
Background: Aim of this work was to improve standardization of the 13C-urea breath test (13C-UBT) by evaluating the effect of drug administration, feeding and colonic ureolysis on the UBT results.
Methods: Three different studies were performed. First, a 13C-UBT was performed in 41 Helicobacter pylori infected subjects before and after 1 day of therapy with sucralfate (5 g), colloidal bismuth (600 mg), amoxycillin (2.5 g) or omeprazole (40 mg). Second, a 13C-UBT was performed in 10 H. pylori-positive patients after an overnight fast and repeated 2 h after lunch. Finally, a 13C-UBT was carried out in seven healthy volunteers, with breath sampling prolonged to 6 h to investigate colonic bacterial ureolysis.
Results: Even a short course of drugs specific for H. pylori may result in a falsely negative 13C-UBT. Feeding does not interfere with the 13C-UBT in infected subjects. No significant 13C-urea breakdown by colonic bacteria is observed during the 13C-UBT when it is prolonged to 6 h.
Conclusion: The 13C-urea breath test is a sensitive clinical tool for the non-invasive diagnosis of H. pylori infection. It is unaffected by feeding or colonic ureolysis. However, false negative results are likely even after 1 day of therapy with bactericidal, ‘cytoprotective’ or antisecretory drugs.