• 1
    Badiali D, Corazziari E, Habib FI, et al. Effect of wheat bran in treatment of chronic nonorganic constipation. A double-blind controlled trial. Dig Dis Sci 1995; 40: 34956.
  • 2
    Graham DY, Moser SE, Estes MK. The effect of bran on bowel function in constipation. Am J Gastroenterol 1982; 77: 599603.
  • 3
    Francis CY, Whorwell PJ. Bran and irritable bowel syndrome: time of reappraisal. Lancet 1994; 344: 3940.
  • 4
    Schiller LR. Review article: the therapy of constipation. Aliment Pharmacol Ther 2001; 15: 74963.
  • 5
    Thompson WG. Laxatives: clinical pharmacology and practical use. Drugs 1980; 19: 4958.
  • 6
    Clausen MR, Mortensen PB. Lactulose, disaccharides and colonic flora. Clinical consequences. Drugs 1997; 53: 93042.
  • 7
    Sanders JF. Lactulose syrup assessed in a double-blind study of elderly constipated patients. J Am Geriatr Soc 1978; 26: 2369.
  • 8
    Lederle FA, Busch DL, Mattox KM, et al. Cost-effective treatment of constipation in the elderly: a randomized double-blind comparison of sorbitol and lactulose. Am J Med 1990; 89: 597601.
  • 9
    Passmore AP, Wilson-Davies K, Stoker C, et al. Chronic constipation in long-stay elderly patients: a comparison of lactulose and a senna-fibre combination. Br Med J 1993; 307: 76971.
  • 10
    Ballongue J, Schumann C, Quignon P. Effects of lactulose and lactitol on colonic microflora and enzymatic activity. Scand J Gastroenterol 1997; 32: 414.
  • 11
    Bouhnik Y, Riottot M, Telotte A, et al. Lactulose ingestion increases fecal bifidobacterial counts. A randomized double blind study in healthy humans. Eur J Clin Nutr 2004; 58: 4626.
  • 12
    Nagengast FM, Hectors MP, Buys WA, et al. Inhibition of secondary bile acid formation in the large intestine by lactulose in healthy subjects of two different age groups. Eur J Clin Invest 1988; 18: 5661.
  • 13
    Florent C, Flourié B, Leblond A, et al. Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in vivo study). J Clin Invest 1985; 75: 60813.
  • 14
    Evans DF, Pye G, Bramley R, et al. Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 1988; 29: 103541.
  • 15
    Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 1995; 125: 140112.
  • 16
    Andorsky RI, Goldner F. Colonic lavage solution (polyethylene glycol electrolyte lavage solution) as a treatment for chronic constipation: a double-blind, placebo-controlled study. Am J Gastroenterol 1990; 85: 2615.
  • 17
    DiPalma JA, DeRidder PH, Orlando RC, et al. Randomized, placebo-controlled, multicenter study of the safety and efficacy of a new polyethylene glycol laxative. Am J Gastroenterol 2000; 95: 44650.
    Direct Link:
  • 18
    Drossman DA, ed. The Functional Gastrointestinal Disorders. Boston: Little, Brown, 1994: 11573.
  • 19
    Bouhnik Y, Pochart P, Marteau P, et al. Fecal recovery in humans of viable Bifidobacterium sp ingested in fermented milk. Gastroenterology 1992; 102: 8758.
  • 20
    Stephen AM, Cummings JH. The microbial contribution to human faecal mass. J Med Microbiol 1980; 13: 4556.
  • 21
    Lowry OH, Rosebrough NJ, Farr AL, et al. Protein measurement with Folin phenol reagent. J Biol Chem 1951; 193: 26575.
  • 22
    Riottot M, Olivier P, Huet A, et al. Hypolipidemic effects of beta-cyclodextrin in the hamster and in the genetically hypercholesterolemic Rico rat. Lipids 1993; 28: 1818.
  • 23
    Stempfel RS, Sidbury JB. Studies with the hydroxysteroid deshydrogenase. A simplified method for the enzymatic estimation of 3 and 17 hydroxysteroids. J Clin Endocrinol 1964; 24: 36772.
  • 24
    Zijlstra JB, Beukema J, Wolthers BG, et al. Pretreatment methods prior to chromatographic analysis of volatile fatty acids from faecal samples. Clin Chim Acta 1977; 78: 24350.
  • 25
    Guerrant GO, Lambert MA, Moss CW. Analysis of short chain fatty acids from anaerobic bacteria by high performance liquid chromatography. J Clin Microbiol 1982; 16: 35560.
  • 26
    Stein J, Kulemeier B, Lembcke B, et al. Simple and rapid method for determination of short-chain fatty acids in biological materials by high-performance liquid chromatography with ultraviolet detection. J Chromatogr 1992; 576: 5361.
  • 27
    Sobhani I, Sansarricq M, Flourie B. [Laxative effect and tolerance of lactulose administered in one or two intakes in the treatment of chronic idiopathic constipation. Groupe d'Investigateurs d'Ile-de-France (GIIF)]. Gastroenterol Clin Biol 1996; 20: 3626.
  • 28
    Attar A, Lemann M, Ferguson A, et al. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut 1999; 44: 22630.
  • 29
    Conn HO, Floch MH. Effects of lactulose and Lactobacillus acidophilus on the fecal flora. Am J Clin Nutr 1970; 23: 158894.
  • 30
    Terada A, Hara H, Kataoka M, et al. Effect of lactulose on composition and metabolic activity of the human fecal flora. Microb Ecol Health Dis 1992; 5: 4350.
  • 31
    Mitsuoka T. Intestinal flora and aging. Nutr Rev 1992; 50: 43846.
  • 32
    Kleessen B, Sykura B, Zunft HJ, et al. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 1997; 65: 1397402.
  • 33
    Ouwehand AC, Isolauri E, Kirjavainen PV, et al. Adhesion of four Bifidobacterium strains to human intestinal mucus from subjects in different age groups. FEMS Microbiol Lett 1999; 172: 614.
  • 34
    Roy D, Berger JL, Reuter G. Characterization of dairy-related Bifidobacterium spp. based on their beta-galactosidase electrophoretic patterns. Int J Food Microbiol 1994; 23: 5570.
  • 35
    Favier C, Neut C, Mizon C, et al. Fecal β-d-galactosidase production and bifidobacteria are decreased in Crohn's disease. Dig Dis Sci 1997; 42: 81722.
  • 36
    Hammer HF, Santa Ana CA, Schiller LR, et al. Studies of osmotic diarrhea induced in normal subjects by ingestion of polyethylene glycol and lactulose. J Clin Invest 1989; 84: 105662.
  • 37
    Malhotra SL. Faecal urobilinogen levels and pH of stools in population groups with different incidence of cancer of the colon, and their possible role in its aetiology. J R Soc Med 1982; 75: 70914.
  • 38
    Samelson SL, Nelson RL, Nyhus LM. Protective role of faecal pH in experimental colon carcinogenesis. J R Soc Med 1985; 78: 2303.
  • 39
    Pryde SE, Duncan SH, Hold GL, et al. The microbiology of butyrate formation in the human colon. FEMS Microbiol Lett 2002; 217: 1339.
  • 40
    Reddy BS, Watanabe K, Weisburger JH, et al. Promoting effect of bile acids in colon carcinogenesis in germ free and conventional F344 rats. Cancer Res 1977; 37: 323842.
  • 41
    Gorbach SL, Goldin BR. The intestinal microflora and the colon cancer connection. Rev Infect Dis 1990; 12: S25261.
  • 42
    Hori T, Matsumoto K, Sakaitani Y, et al. Effect of dietary deoxycholic acid and cholesterol on fecal steroid concentration and its impact on the colonic crypt cell proliferation in azoxymethane-treated rats. Cancer Lett 1998; 124: 7984.
  • 43
    Nair PP. Role of bile acids and neutral sterols in carcinogenesis. Am J Clin Nutr 1988; 48: 76874.
  • 44
    Owen RW. Faecal steroids and colorectal carcinogenesis. Scand J Gastroenterol 1997; 222: 7682.
  • 45
    Nagengast FM, Grubben MJ, Van Munster IP. Role of bile acids in colorectal carcinogenesis. Eur J Cancer 1995; 31A: 106770.
  • 46
    Finegold SM, Sutter VL, Mathisen GE. Normal indigenous intestinal flora. In: HentgesDJ, ed. Human Intestinal Microflora in Health and Disease. New York: Academic Press, 1983: 331.