Influence of a lipase inhibitor on gastric sensitivity and accommodation to an orally ingested meal
Article first published online: 1 JUN 2004
Alimentary Pharmacology & Therapeutics
Volume 19, Issue 12, pages 1261–1268, June 2004
How to Cite
Demarchi, B., Vos, R., Deprez, P., Janssens, J. and Tack, J. (2004), Influence of a lipase inhibitor on gastric sensitivity and accommodation to an orally ingested meal. Alimentary Pharmacology & Therapeutics, 19: 1261–1268. doi: 10.1111/j.1365-2036.2004.02003.x
- Issue published online: 4 JUN 2004
- Article first published online: 1 JUN 2004
- Accepted for publication 12 April 2004
Background : Intraduodenal administration of lipids, through lipid digestion and release of cholecystokinin (CCK), induces viscero-visceral reflexes that affect gastric tone and sensitivity. It is unclear whether the same mechanisms control gastric function after an orally ingested meal.
Aim : To evaluate the effect of orlistat, a selective lipase inhibitor, on gastric response to an orally administered meal.
Methods : Eighteen healthy volunteers participated in this study. They were treated for 5 days with orlistat (120 mg) or placebo t.d.s. in a double-blind randomized crossover design. During treatment, all subjects underwent a gastric barostat study, measurement of plasma CCK levels and a satiety drinking test.
Results : Although CCK plasma levels were significantly decreased, pre-treatment with orlistat failed to affect gastric compliance (72 ± 6 mL/mm Hg and 64 ± 6 mL/mm Hg, NS), gastric sensitivity (discomfort threshold 12.2 ± 0.6 mm Hg vs. 10.9 ± 0.6 mm Hg above minimal distending pressure, NS) or gastric accommodation (172 ± 41 mL vs. 206 ± 49 mL, NS) to an orally ingested meal. Furthermore, orlistat pre-treatment had no significant effect on the amount of calories ingested during a satiety drinking test (1329 ± 88 kcal vs. 1217 ± 115 kcal, NS).
Conclusion : Administration of a lipase inhibitor does not affect gastric compliance, sensitivity to distension and accommodation to an orally ingested meal, and does not influence meal-induced satiety.