• 1
    Mitchell CM, Drossman DA. Survey of the AGA membership relating to patients with functional gastrointestinal disorders. Gastroenterology 1987; 92: 12824.
  • 2
    Drossman DA, Whitehead WE, Camilleri M. Irritable bowel syndrome: a technical review for practice guideline development. Gastroenterology 1997; 112: 212037.
  • 3
    Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ. Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology 1992; 102: 125968.
  • 4
    Locke GR 3rd. Prevalence, incidence and natural history of dyspepsia and functional dyspepsia. Baillieres Clin Gastroenterol 1998; 12: 43542.DOI: 10.1016/S0950-3528(98)90016-1
  • 5
    Tougas G, Chen Y, Hwang P, Liu MM, Eggleston A. Prevalence and impact of upper gastrointestinal symptoms in the Canadian population: findings from the DIGEST study. Domestic / International Gastroenterology Surveillance Study. Am J Gastroenterol 1999; 94: 284554.DOI: 10.1016/S0002-9270(99)00483-9
    Direct Link:
  • 6
    Talley NJ, Weaver AL, Zinsmeister AR, Melton LJ III. Onset and disappearance of gastrointestinal symptoms and functional gastrointestinal disorders. Am J Epidemiol 1992; 136: 16577.
  • 7
    Pare P. Systematic approach toward the clinical diagnosis of functional dyspepsia. Can J Gastroenterol 1999; 13: 64754.
  • 8
    Drossman DA, Li Z, Andruzzi E, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography and health impact. Dig Dis Sci 1993; 38: 156980.
  • 9
    Sonnenberg A, Koch TR. Physician visits in the United States for constipation: 1958–1986. Dig Dis Sci 1989; 34: 60611.
  • 10
    Heaton KW, Radvan J, Cripps H, Mountford RA, Braddon FE, Hughes AO. Defecation frequency and timing, and stool form in the general population: a prospective study. Gut 1992; 33: 81824.
  • 11
    Talley NJ, Weaver AL, Zinsmeister AR, Melton JM III. Functional constipation and outlet delay: a population-based study. Gastroenterology 1993; 105: 78190.
  • 12
    Pare P, Ferrazzi S, Thompson WG, Irvine EJ, Rance L. An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking. Am J Gastroenterol 2001; 96: 31307.
    Direct Link:
  • 13
    Drossman DA, Sandler RS, McKee DC, Lovitz AJ. Bowel patterns among subjects not seeking health care. Use of a questionnaire to identify a population with bowel dysfunction. Gastroenterology 1982; 83: 52934.
  • 14
    Thompson WG, Heaton KW. Functional bowel disorders in apparently healthy people. Gastroenterology 1980; 79: 2838.
  • 15
    American Gastroenterological Association. The Burden of Gastrointestinal Diseases. Bethesda MD: American Gastroenterological Association Press, 2002.
  • 16
    Talley NJ, Gabriel SE, Harmsen WS, Zinsmeister AR, Evans RW. Medical costs in community subjects with irritable bowel syndrome. Gastroenterology 1995; 109: 173641.
  • 17
    Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology 2002; 122: 150011.
  • 18
    Chang L, Heitkemper MM. Gender differences in irritable bowel syndrome. Gastroenterology 2002; 123: 1686701.
  • 19
    Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology 1997; 112: 144856.
  • 20
    Cormier LE, Katon W, Russo J, Hollifield M, Hall ML, Vitaliano PP. Chest pain with negative cardiac diagnostic studies. Relationship to psychiatric illness. J Nerv Ment Dis 1988; 176: 3518.
  • 21
    Drossman DA, Corazziari E, Talley NJ, et al., eds. ROME II. The Functional Gastrointestinal Disorders. Diagnosis, Pathophysiology and Treatment: A Multinational Consensus, 2nd edn. McLean, VA: Degnon Associates, 2000.
  • 22
    Talley NJ, Verlinden M, Jones M. Can symptoms discriminate among those with delayed or normal gastric emptying in dysmotility-like dyspepsia? Am J Gastroenterol 2001; 96: 14228.
    Direct Link:
  • 23
    Stanghellini V, Tosetti C, Paternico A, et al. Risk indicators of delayed gastric emptying of solids in patients with functional dyspepsia. Gastroenterology 1996; 110: 103642.
  • 24
    Strid H, Norstrom M, Sjoberg J, Simren M, Svedlund J. Impact of sex and psychological factors on the water loading test in functional dyspepsia. Scand J Gastroenterol 2001; 36: 72530.DOI: 10.1080/003655201300191987
  • 25
    Camilleri M. Management of the irritable bowel syndrome. Gastroenterology 2001; 120: 65268.
  • 26
    Saito YA, Locke GR, Talley NJ, Zinsmeister AR, Fett SL, Melton LJ 3rd. A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome. Am J Gastroenterol 2000; 95: 281624.
    Direct Link:
  • 27
    Jain AP, Gupta OP, Jajoo UN, Sidhwa HK. Clinical profile of irritable bowel syndrome at a rural based teaching hospital in central India. J Assoc Physicians India 1991; 39: 3856.
  • 28
    Lu CL, Chen CY, Lang HC, et al. Current patterns of irritable bowel syndrome in Taiwan: the Rome II questionnaire on a Chinese population. Aliment Pharmacol Ther 2003; 17: 21724.DOI: 10.1046/j.1365-2036.2003.01418.x
  • 29
    Saito YA, Talley NJ, Melton L, Fett S, Zinsmeister AR, Locke GR. The effect of new diagnostic criteria for irritable bowel syndrome on community prevalence estimates. Neurogastroenterol Motil 2003; 15: 68794.DOI: 10.1046/j.1350-1925.2003.00441.x
  • 30
    Talley NJ, Boyce P, Jones M. Identification of distinct upper and lower gastrointestinal symptom groupings in an urban population. Gut 1998; 42: 6905.
  • 31
    Lee OY, Mayer EA, Schmulson M, Chang L, Naliboff B. Gender-related differences in IBS symptoms. Am J Gastroenterol 2001; 96: 218493.
    Direct Link:
  • 32
    Corney RH, Stanton R. Physical symptom severity, psychological and social dysfunction in a series of outpatients with irritable bowel syndrome. J Psychosom Res 1990; 34: 48391.
  • 33
    Simren M, Abrahamsson H, Svedlund J, Bjornsson ES. Quality of life in patients with irritable bowel syndrome seen in referral centers versus primary care: the impact of gender and predominant bowel pattern. Scand J Gastroenterol 2001; 36: 54552.DOI: 10.1080/003655201750153476
  • 34
    Everhart JE, Go VLW, Johannes RS, Fitzsimmons SC, Roth HP, White LR. A longitudinal survey of self-reported bowel habits in the United States. Dig Dis Sci 1989; 34: 115362.
  • 35
    Stewart WF, Liberman JN, Sandler RS, et al. Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol 1999; 94: 353040.DOI: 10.1016/S0002-9270(99)00701-7
    Direct Link:
  • 36
    Levy RL, Von Korff M, Whitehead WE, et al. Costs of care for irritable bowel syndrome patients in a health maintenance organization. Am J Gastroenterol 2001; 96: 31229.
    Direct Link:
  • 37
    Longstreth GF, Wilson A, Knight K, et al. Irritable bowel syndrome, health care use, and costs: a U.S. managed care perspective. Am J Gastroenterol 2003; 98: 6007.
    Direct Link:
  • 38
    Martin BC, Ganguly R, Pannicker S, Frech F, Barghout V. Utilization patterns and net direct medical cost to Medicaid of irritable bowel syndrome. Curr Med Res Opin 2003; 19: 77180.DOI: 10.1185/030079903125002540
  • 39
    Hasler WL, Schoenfeld P. Systematic review: abdominal and pelvic surgery in patients with irritable bowel syndrome. Aliment Pharmacol Ther 2003; 17: 9971005.
  • 40
    Longstreth GF, Yao JF. Irritable bowel syndrome and surgery: a multivariable analysis. Gastroenterology 2004; 126: 166573.
  • 41
    Frank L, Kleinman L, Rentz A, Ciesla G, Kim JJ, Zacker C. Health-related quality of life associated with irritable bowel syndrome: comparison with other chronic diseases. Clin Ther 2002; 24: 67589.DOI: 10.1016/S0149-2918(02)85143-8
  • 42
    Gralnek IM, Hays RD, Kilbourne A, Naliboff B, Mayer EA. The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology 2000; 119: 65460.
  • 43
    American College of Gastroenterology Functional Gastrointestinal Disorders Task Force. Evidence-based position statement on the management of irritable bowel syndrome in North America. Am J Gastroenterol 2002; 97(Suppl.): S15.
  • 44
    El-Serag HB, Talley NJ. Health-related quality of life in functional dyspepsia. Aliment Pharmacol Ther 2003; 18: 38793.DOI: 10.1046/j.1365-2036.2003.01706.x
  • 45
    Mones J, Adan A, Segu JL, Lopez JS, Artes M, Guerrero T. Quality of life in functional dyspepsia. Dig Dis Sci 2002; 47: 206.DOI: 10.1023/A:1013294815971
  • 46
    Talley NJ, Weaver AL, Zinsmeister AR. Impact of functional dyspepsia on quality of life. Dig Dis Sci 1995; 40: 5849.
  • 47
    Wiklund I, Glise H, Jerndal P, Carlsson J, Talley NJ. Does endoscopy have a positive impact on quality of life in dyspepsia? Gastrointest Endosc 1998; 47: 44954.
  • 48
    Halder SL, Locke GR 3rd, Talley NJ, Fett SL, Zinsmeister AR, Melton LJ 3rd. Impact of functional gastrointestinal disorders on health-related quality of life: a population-based case–control study. Aliment Pharmacol Ther 2004; 19: 23342.
  • 49
    Koloski NA, Talley NJ, Boyce PM. The impact of functional gastrointestinal disorders on quality of life. Am J Gastroenterol 2000; 95: 6771.
    Direct Link:
  • 50
    Badia X, Mearin F, Balboa A, et al. Burden of illness in irritable bowel syndrome comparing Rome I and Rome II criteria. Pharmacoeconomics 2002; 20: 74958.
  • 51
    Meineche-Schmidt V, Krag E. Dyspepsia in general practice in Denmark. A 1-year analysis of consulters in general practice. Scand J Prim Health Care 1998; 16: 21621.DOI: 10.1080/028134398750002981
  • 52
    Calvert EL, Houghton LA, Cooper P, Morris J, Whorwell PJ. Long-term improvement in functional dyspepsia using hypnotherapy. Gastroenterology 2002; 123: 177885.
  • 53
    Talley NJ, Verlinden M, Jones M. Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form. Aliment Pharmacol Ther 2001; 15: 20716.DOI: 10.1046/j.1365-2036.2001.00900.x
  • 54
    El-Serag HB. Impact of irritable bowel syndrome: prevalence and effect on health-related quality of life. Rev Gastroenterol Disord 2003; 3: S311.
  • 55
    Mathias JR, Clench MH, Abell TL, et al. Effect of leuprolide acetate in treatment of abdominal pain and nausea in premenopausal women with functional bowel disease: a double-blinded, placebo-controlled, randomized study. Dig Dis Sci 1998; 43: 134755.DOI: 10.1023/A:1018888631286
  • 56
    Heymann-Monnikes I, Arnold R, Florin I, Herda C, Melfsen S, Monnikes H. The combination of medical treatment plus multicomponent behavioral therapy is superior to medical treatment alone in the therapy of irritable bowel syndrome. Am J Gastroenterol 2000; 95: 98194.
  • 57
    Camilleri M, Mayer EA, Drossman DA, et al. Improvement in pain and bowel function in female irritable bowel patients with alosetron, a 5-HT3 receptor antagonist. Aliment Pharmacol Ther 1999; 13: 114959.
  • 58
    Camilleri M, Northcutt AR, Kong S, Dukes GE, McSorley D, Mangel AW. Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised placebo-controlled trial. Lancet 2000; 355: 103540.
  • 59
    Camilleri M, Chey WY, Mayer EA, et al. A randomized controlled clinical trial of the serotonin type 3 receptor antagonist alosetron in women with diarrhea-predominant irritable bowel syndrome. Arch Intern Med 2001; 161: 173340.
  • 60
    Lembo T, Wright RA, Bagby B, et al. Alosetron controls bowel urgency and provides global symptom improvement in women with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2001; 96: 266270.
    Direct Link:
  • 61
    Watson ME, Lacey L, Kong S, et al. Alosetron improves quality of life in women with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 2001; 96: 4559.
    Direct Link:
  • 62
    Drossman DA, Toner BB, Whitehead WE, et al. Cognitive-behavioral therapy versus education and desipramine versus placebo for moderate to severe functional bowel disorders. Gastroenterology 2003; 125: 1931.DOI: 10.1016/S0016-5085(03)00669-3
  • 63
    Naliboff BD, Mayer M, Fass R, et al. The effect of life stress on symptoms of heartburn. Psychosom Med 2004; 66(3): 42634.
  • 64
    Biggs AM, Aziz Q, Tomenson B, Creed F. Effect of childhood adversity on health related quality of life in patients with upper abdominal or chest pain. Gut 2004; 53: 1806.
  • 65
    Spiegel BMR, Gralnek IM, Mayer EA, et al. Clinical determinants of health-related quality of life in irritable bowel syndrome. Arch Intern Med 2004; 164: 177380.
  • 66
    Appels A. Mental precursors of myocardial infarction. Br J Psychiatry 1990; 156: 46571.
  • 67
    Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology 2002; 123: 210831.DOI: 10.1053/gast.2002.37095