Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease – where next?
Article first published online: 12 JUL 2005
Alimentary Pharmacology & Therapeutics
Volume 22, Issue 2, pages 79–94, July 2005
How to Cite
FASS, R., SHAPIRO, M., DEKEL, R. and SEWELL, J. (2005), Systematic review: proton-pump inhibitor failure in gastro-oesophageal reflux disease – where next?. Alimentary Pharmacology & Therapeutics, 22: 79–94. doi: 10.1111/j.1365-2036.2005.02531.x
- Issue published online: 12 JUL 2005
- Article first published online: 12 JUL 2005
- Accepted for publication 30 April 2005
Proton-pump inhibitor failure has become a common clinical dilemma in gastrointestinal clinics and has been increasingly encountered at the primary care level as well. Underlying mechanisms are diverse and may overlap. Most patients who have proton-pump inhibitor failure are likely to originate from the non-erosive reflux disease phenotype. Currently, available diagnostic modalities provide limited clues to the exact underlying cause. Treatment relies primarily on escalating dosing of proton-pump inhibitors. However, new insights into the pathophysiology of proton-pump inhibitor failure are likely to provide alternative therapeutic options.