• 1
    Chu CM, Yeh CT, Chien RN, Sheen IS, Liaw YF. The degrees of hepatocyte nuclear but not cytoplasmic expression of hepatitis B core antigen reflect the level of viral replication in chronic hepatitis B virus infection. J Clin Microbiol 1997; 35: 1025.
  • 2
    Naoumov NV, Portmann BC, Tedder RS, et al. Detection of hepatitis B virus antigens in liver tissue. A relation to viral replication and histology in chronic hepatitis B infection. Gastroenterology 1990; 99: 124853.
  • 3
    Aiba N, McGarvey MJ, Waters J, Hadziyannis SJ, Thomas HC, Karayiannis P. The precore sequence of hepatitis B virus is required for nuclear localization of the core protein. Hepatology 1997; 26: 13117.
  • 4
    Naoumov NV, Schneider R, Grotzinger T, et al. Precore mutant hepatitis B virus infection and liver disease. Gastroenterology 1992; 102: 53843.
  • 5
    Dienes HP, Gerken G, Goergen B, Heermann K, Gerlich W, Meyer zum Buschenfelde KH. Analysis of the precore DNA sequence and detection of precore antigen in liver specimens from patients with anti-hepatitis B e-positive chronic hepatitis. Hepatology 1995; 21: 17.
  • 6
    Park YN, Han KH, Kim KS, Chung JP, Kim S, Park C. Cytoplasmic expression of hepatitis B core antigen in chronic hepatitis B virus infection: role of precore stop mutants. Liver 1999; 19: 199205.
  • 7
    Okamoto H, Tsuda F, Akahane Y, et al. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen. J Virol 1994; 68: 810210.
  • 8
    Yuen MF, Sablon E, Yuan HJ, et al. Relationship between the development of precore and core promoter mutations and hepatitis B e antigen seroconversion in patients with chronic hepatitis B virus. J Infect Dis 2002; 186: 13351338.
  • 9
    Chan HL, Hussain M, Lok AS. Different hepatitis B virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion. Hepatology 1999; 29: 97684.
  • 10
    Stuyver L, De Gendt S, Cadranel JF, et al. Three cases of severe subfulminant hepatitis in heart-transplanted patients after nosocomial transmission of a mutant hepatitis B virus. Hepatology 1999; 29: 187683.
  • 11
    Ferns RB, Tedder RS. Monoclonal antibodies to hepatitis Be antigen (HBeAg) derived from hepatitis B core antigen (HBcAg): their use in characterization and detection of HBeAg. J Gen Virol 1984; 65: 899908.
  • 12
    Knodell RG, Ishak KG, Black WC, et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981; 1: 4315.
  • 13
    Lindh M, Hannoun C, Dhillon AP, Norkrans G, Horal P. Core promoter mutations and genotypes in relation to viral replication and liver damage in East Asian hepatitis B virus carriers. J Infect Dis 1999; 179: 775782.
  • 14
    Lindh M, Gustavson C, Mardberg K, Norkrans G, Dhillon AP, Horal P. Mutation of nucleotide 1,762 in the core promoter region during hepatitis B e seroconversion and its relation to liver damage in hepatitis B e antigen carriers. J Med Virol 1998; 55: 18590.
  • 15
    Baumert TF, Marrone A, Vergalla J, Liang TJ. Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression. J Virol 1998; 72: 678595.
  • 16
    Yeh CT, Wong SW, Fung YK, Ou JH. Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci USA 1993; 90: 645963.
  • 17
    Chu CM, Yeh CT, Sheen IS, Liaw YF. Subcellular localization of hepatitis B core antigen in relation to hepatocyte regeneration in chronic hepatitis B. Gastroenterology 1995; 109: 192632.
  • 18
    Gunther S, Fischer L, Pult I, Sterneck M, Will H. Naturally occurring variants of hepatitis B virus. Adv Virus Res 1999; 52: 25137.
  • 19
    Villari D, Pollicino T, Spinella S, et al. Hepatitis B E antigen detection in formalin-fixed liver biopsy specimens. A tool to investigate wild-type and E-minus variant HBV infection. Am J Clin Pathol 1995; 103: 13640.
  • 20
    Schneider R, Fernholz D, Wildner G, Will H. Mechanism, kinetics, and role of duck hepatitis B virus e-antigen expression in vivo. Virology 1991; 182: 50312.
  • 21
    Lindh M, Horal P, Dhillon AP, Furuta Y, Norkrans G. Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage. Hepatology 1996; 24: 494501.
  • 22
    Lindh M, Savage K, Rees J, et al. HBeAg immunostaining of liver tissue in various stages of chronic hepatitis B. Liver 1999; 19: 2948.