Autoantibody profile during short-term infliximab treatment for Crohn's disease: a prospective cohort study
Article first published online: 26 AUG 2005
Alimentary Pharmacology & Therapeutics
Volume 22, Issue 5, pages 453–461, September 2005
How to Cite
ATZENI, F., ARDIZZONE, S., SARZI-PUTTINI, P., COLOMBO, E., MACONI, G., DE PORTU, S., CARRABBA, M. and BIANCHI PORRO, G. (2005), Autoantibody profile during short-term infliximab treatment for Crohn's disease: a prospective cohort study. Alimentary Pharmacology & Therapeutics, 22: 453–461. doi: 10.1111/j.1365-2036.2005.02576.x
- Issue published online: 26 AUG 2005
- Article first published online: 26 AUG 2005
- Accepted for publication 19 June 2005
Background : The potential clinical implications of autoimmunity during treatment with infliximab are unclear.
Aim : To determine the frequency and correlation of autoantibody formation in patients with Crohn's disease treated with infliximab in a routine clinical setting.
Methods : Sixty-three patients with refractory/inflammatory (31) and/or fistulising Crohn's disease (32), received an infliximab infusion at a dose 5 mg/kg in weeks 0, 2 and 6, and were evaluated for the development of antinuclear, anti-double-stranded DNA, anti-Sm, anti-RNP, anti-SSA, anti-SSB and antihistone antibodies. The correlates with pharmacological treatments, the response to infliximab and adverse events were evaluated.
Results : Antinuclear antibodies were found in five of the 63 patients (8%) at baseline and in 26 (42%) after 10 weeks (P < 0.001). Of the 26 antinuclear antibody-positive patients who were further subtyped, nine of 63 (17%) had anti-double-stranded DNA (P = 0.003), and 1.5% were extractable nuclear antigen (ENA) and antihistone-positive. Five patients were initially positive for anticardiolipin antibodies and two more patients became positive during infliximab treatment. New autoantibody formation was more frequent in the patients with inflammatory/refractory disease than in those with fistulising disease (17 vs. 7; P = 0.02). One patient developed drug-induced lupus without major organ damage.
Conclusions : Autoantibody formation occurs in 42% of patients (8% of these patients were positive before infliximab treatment) with Crohn's disease receiving induction treatment with infliximab, but the clinical significance of this remains to be determined.