These authors contributed equally to this study.
Comparative evaluation of a new bedside faecal occult blood test in a prospective multicentre study
Article first published online: 13 DEC 2005
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 1, pages 145–154, January 2006
How to Cite
HOEPFFNER, N., SHASTRI, Y. M., HANISCH, E., RÖSCH, W., MÖSSNER, J., CASPARY, W. F. and STEIN, J. (2006), Comparative evaluation of a new bedside faecal occult blood test in a prospective multicentre study. Alimentary Pharmacology & Therapeutics, 23: 145–154. doi: 10.1111/j.1365-2036.2006.02702.x
- Issue published online: 13 DEC 2005
- Article first published online: 13 DEC 2005
- Publication data Submitted 23 August 2005 First decision 12 September 2005 Resubmitted 29 September 2005 Accepted 29 September 2005
Faecal occult blood testing is an established method of colorectal neoplasia screening. Guaiac-based tests are limited by poor patient compliance, low sensitivity, specificity and positive predictive value. Newer immunochemical-based tests, accurate but tedious, require a well-established laboratory set up. There is need for simpler immunochemical tests that can be performed at the out-patient clinic.
To compare the performance characteristics of a new bedside immunological test strip device with a sensitive Guaiac-based and established immunochemical test for detection of faecal occult blood in patients undergoing colonoscopy.
A total of 389 consecutive patients from four centres who were referred for colonoscopy also provided the stool samples for detection of occult blood without dietary restrictions. Stool tests performed were (i) Guaiac-based, (ii) immunochemical enzyme-linked immunosorbent assay and (iii) bedside immunochemical strip test.
At the optimal threshold level, the sensitivity and specificity of the beside immunochemical strip test for detection of significant colorectal neoplasia (adenomas >1.0 cm and carcinomas) were 60% and 95%, respectively.
This bedside immunochemical strip test proved to be a simple, convenient, non-cumbersome and accurate tool with similar performance characteristics for detection of any bleeding lesion including colorectal neoplasia when compared with an established immunochemical faecal occult blood test.