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The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups
Article first published online: 22 DEC 2005
DOI: 10.1111/j.1365-2036.2006.02747.x
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How to Cite
SHAPIRO, M., GREEN, C., FAYBUSH, E. M., ESQUIVEL, R. F. and FASS, R. (2006), The extent of oesophageal acid exposure overlap among the different gastro-oesophageal reflux disease groups. Alimentary Pharmacology & Therapeutics, 23: 321–329. doi: 10.1111/j.1365-2036.2006.02747.x
Publication History
- Issue published online: 22 DEC 2005
- Article first published online: 22 DEC 2005
- Publication data Submitted 29 July 2005 First decision 25 August 2005 Resubmitted 7 October 2005 Resubmitted 21 October 2005 Accepted 23 October 2005
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Summary
Background Studies have demonstrated that patients with Barrett's oesophagus have the highest oesophageal acid exposure profile, followed by erosive oesophagitis and non-erosive reflux disease patients, but the exact extent of overlap remains unknown.
Aim To determine the extent of overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups.
Methods A total of 121 patients with gastro-oesophageal reflux disease underwent an upper endoscopy and were classified as having Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-all (non-erosive reflux disease-positive and functional heartburn). Subsequently, patients underwent pH testing and overlap in oesophageal acid exposure among the different gastro-oesophageal reflux disease groups was determined.
Results Of those enrolled, 24 had Barrett's oesophagus, 30 erosive oesophagitis and 28 were non-erosive reflux disease-positive. Mean oesophageal acid exposure time was 224.8 ± 35, 134.3 ± 21.9 and 141.3 ± 19.8 min for Barrett's oesophagus, erosive oesophagitis and non-erosive reflux disease-positive respectively. Per cent overlap for total, upright and supine time between non-erosive reflux disease-positive and erosive oesophagitis was 47.4%, 64.7% and 81.8%, between Barrett's oesophagus and erosive oesophagitis was 47.8%, 40.7% and 24%, and between Barrett's oesophagus and non-erosive reflux disease-positive was 31.6%, 37.5% and 20.8% respectively.
Conclusions Our study demonstrated a high oesophageal acid exposure overlap between patients with non-erosive reflux disease-positive and erosive oesophagitis, Barrett's oesophagus and erosive oesophagitis, as well as Barrett's oesophagus and non-erosive reflux disease-positive patients.