Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study
Article first published online: 14 FEB 2006
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 5, pages 675–680, March 2006
How to Cite
GUI, D., MINGRONE, G., VALENZA, V., SPADA, P. L., MUTIGNANI, M., RUNFOLA, M., SCARFONE, A., DI MUGNO, M. and PANUNZI, S. (2006), Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot study. Alimentary Pharmacology & Therapeutics, 23: 675–680. doi: 10.1111/j.1365-2036.2006.02773.x
- Issue published online: 14 FEB 2006
- Article first published online: 14 FEB 2006
- Publication data Submitted 14 September 2005 First decision 2 October 2005 Resubmitted 13 October 2005 Resubmitted 22 November 2005 Accepted 22 November 2005
Background A potential approach to the treatment of morbid obesity is reduction of gastric emptying to achieve satiety. Botulinum toxin A (Btx-A) is a long-acting inhibitor of acetylcholine-mediated peristalsis, which is mainly responsible for gastric motility.
Aim To investigate whether botulinum toxin A, injected in the antrum of obese patients, delays gastric emptying.
Methods In a double_blind study, 18 healthy obese subjects (body mass index >30) were randomized into three groups (BTX133, BTX200 and Saline); they received Btx-A133U, Btx-A200U, or saline under endoscopic control. Gastric emptying was tested by scintigraphy before and 10 days after treatment. Body weight variations and appetite sensation were recorded after 5 weeks.
Results Fourteen patients completed the study. The botulinum toxin A-treated groups showed weight reduction, which was not statistically significant. The effects on gastric emptying were variable. Most of the botulinum toxin A treated patients reported a reduced appetite.
Conclusion This pilot clinical trial suggests potential activity of botulinum toxin A for the manipulation of appetite.