The prevalence of Barrett's oesophagus in a cohort of 1040 Canadian primary care patients with uninvestigated dyspepsia undergoing prompt endoscopy
Article first published online: 14 FEB 2006
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 5, pages 595–599, March 2006
How to Cite
VELDHUYZEN VAN ZANTEN, S. J. O., THOMSON, A. B. R., BARKUN, A. N., ARMSTRONG, D., CHIBA, N., WHITE, R. J., ESCOBEDO, S. and SINCLAIR, P. (2006), The prevalence of Barrett's oesophagus in a cohort of 1040 Canadian primary care patients with uninvestigated dyspepsia undergoing prompt endoscopy. Alimentary Pharmacology & Therapeutics, 23: 595–599. doi: 10.1111/j.1365-2036.2006.02813.x
- Issue published online: 14 FEB 2006
- Article first published online: 14 FEB 2006
- Publication data Submitted 28 October 2005 First decision 22 November 2005 Resubmitted 19 December 2005 Accepted 20 December 2005
Background The prevalence of Barrett's oesophagus in patients undergoing gastroscopy may be influenced by possible referral bias.
Aim To present the prevalence of Barrett's oesophagus from the the Canadian Adult Dyspepsia Empirical Therapy Prompt Endoscopy study and to explore potential risk factors for its presence.
Methods Patients had not been on treatment for dyspepsia for 2–4 weeks prior to endoscopy, which was performed within 10 working days of presentation.
Results Barrett's oesophagus was endoscopically suspected in 53 of 1040 cases (5%) and histologically confirmed by the presence of intestinal metaplasia in 25 (2.4%). The prevalence of biopsy-proven Barrett's oesophagus was 4% in patients with dominant reflux-like symptoms. Sixty-four percent with confirmed Barrett's oesophagus had dominant reflux-like symptoms compared with 37% without Barrett's oesophagus. Barrett's oesophagus was more common in patients >50 years of age; 68% of cases were males. The mean duration of symptoms was 10 years, yet 16% had symptoms of <1-year duration. Endoscopic reflux oesophagitis was present in 68% of confirmed Barrett's oesophagus patients.
Conclusions Barrett's oesophagus is confirmed on biopsy in about half of endoscopically suspected Barrett's oesophagus patients. Barrett's oesophagus is more common in males, in those with dominant reflux-like symptoms, and in patients with a longer symptom history.