• 1
    Dent J, Brun J, Fendrick AM, et al. An evidence-based appraisal of reflux disease management: the Genval Workshop Report. Gut 1999; 44: S116.
  • 2
    Sifrim D, Holloway R, Silny J, et al. Acid, non-acid, and gas reflux in patients with gastroesophageal reflux during ambulatory 24-hour pH-impedance recordings. Gastroenterology 2001; 120: 158898.
  • 3
    Koek GH, Tack J, Sifrim D, et al. The role of acid in duodenal gastroesophageal reflux in symptomatic GERD. Am J Gastroenterol 2001; 96: 203340.
    Direct Link:
  • 4
    Jacob P, Kahrilas PJ, Herzon G. Proximal esophageal pH-metry in patients with ‘reflux laryngitis’. Gastroenterology 1991; 100: 3559.
  • 5
    Shaker R, Milbrath M, Ren J, et al. Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis. Gastroenterology 1995; 109: 157582.
  • 6
    Katz PO. Ambulatory esophageal and hypopharyngeal pH monitoring in patients with hoarseness. Am J Gastroenterol 1990; 85: 3840.
  • 7
    Ulualp SO, Toohill RJ, Shaker R. Pharyngeal acid reflux in patients with single and multiple otolaryngologic disorders. Otolaryngol Head Neck Surg 1999; 121: 72530.
  • 8
    Cicala M, Gabbrielli A, Emerenziani S, et al. Effect of endoscopic augmentation of the lower oesophageal sphincter (Gatekeeper reflux repair system) on intraoesophageal dynamic characteristics of acid reflux. Gut 2005; 54: 1836.
  • 9
    Bredenoord AJ, Weusten BL, Curvers WL, Timmer R, Smout AJ. Determinants of perception of heartburn and regurgitation. Gut 2005; 55: 3138.
  • 10
    Weusten BL, Akkermans LM, van Berge-Henegouwen GP, Smout AJ. Symptom perception in gastroesophageal reflux disease is dependent on spatiotemporal reflux characteristics. Gastroenterology 1995; 108: 173944.
  • 11
    Cicala M, Emerenziani S, Caviglia R, et al. Intra-oesophageal distribution and perception of acid reflux in non-erosive gastro-oesophageal reflux disease patients. Aliment Pharmacol Ther 2003; 18: 60513.
  • 12
    Orr Wc, Elsenbruch S, Harnish MJ, Johnson LF. Proximal migration of esophageal acid perfusions during waking and sleep. Am J Gastroenterol 2000; 95: 3742.
    Direct Link:
  • 13
    Emerenziani S, Zhang X, Blondeau K, et al. Gastric fullness, physical activity, and proximal extent of gastroesophageal reflux. Am J Gastroenterol 2005; 100: 12516.
    Direct Link:
  • 14
    van Herwaarden MA, Samsom M, Smout AJ. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other than transient LES relaxations. Gastroenterology 2000; 119: 143946.
  • 15
    Sloan S, Rademaker AW, Kahrilas PJ. Determinants of gastroesophageal junction incompetence: hiatal hernia lower esophageal sphincter, or both. Ann Intern Med 1992; 117: 97782.
  • 16
    Kahrilas PJ, Shi G, Manka M, Joehl RJ. Increased frequency of transient lower esophageal sphincter relaxation induced by gastric distention in reflux patients with hiatal hernia. Gastroenterology 2000; 118: 68895.
  • 17
    Pandolfino JE, Shi G, Trueworthy B, Kahrilas PJ. Esophagogastric junction opening during relaxation distinguishes nonhernia reflux patients, hernia patients, and normal subjects. Gastroenterology 2003; 125: 101824.
  • 18
    Pandolfino JE, Curry J, Shi G, Joehl RJ, Brasseur JG, Kahrilas PJ. Restoration of normal distensive characteristics of the esophagogastric junction after fundoplication. Ann Surg 2005; 242: 438.
  • 19
    Stal P, Lindberg G, Ost A, Iwarzon M, Seensalu R. Gastroesophageal reflux in healthy subjects. Significance of endoscopic findings, histology, age, and sex. Scand J Gastroenterol 1999; 34: 1218.
  • 20
    Petersen H, Johannessen T, Sandvik AK, et al. Relationship between endoscopic hiatus hernia and gastroesophageal reflux symptoms. Scand J Gastroenterol 1991; 26: 9216.
  • 21
    Frazzoni M, De Micheli E, Grisendi A, Savarino V. Hiatal hernia is the key factor determining the lansoprazole dosage required for effective intra-oesophageal acid suppression. Aliment Pharmacol Ther 2002; 16: 8816.
  • 22
    Leite LP, Johnston BT, Barrett J. Ineffective esophageal motility (IEM): the primary finding in patients with non-specific esophageal motility disorders. Dig Dis Sci 1997; 42: 185965.
  • 23
    Kahrilas PJ, Dodds WJ, Hogan WJ. Effect of peristaltic dysfunction on esophageal volume clearance. Gastroenterology 1988; 94: 7380.
  • 24
    Sloan S, Kahrilas PJ. Impairment of esophageal emptying with hiatal hernia. Gastroenterology 1991; 100: 596605.
  • 25
    Mittal RK, Lange RC, Mc Callum RW. Identification and mechanism of delayed esophageal acid clearance in subjects with hiatus hernia. Gastroenterology 1987; 92: 1305.
  • 26
    Tutuian R, Castell DO. Combined multichannel intraluminal impedance and manometry clarifies esophageal function abnormalities: study in 350 patients. Am J Gastroenterol 2004; 99: 10119.
    Direct Link:
  • 27
    Simren M, Silny J, Holloway R, Tack J, Janssens J, Sifrim D. Relevance of ineffective oesophageal motility during oesophageal acid clearance. Gut 2003; 52: 78490.
  • 28
    Dodds WJ, Walter B. Cannon Lecture: current concepts of esophageal motor function: clinical implications for radiology. AJR Am J Roentgenol 1977; 128: 54961.
  • 29
    Hosmer DW, Lemeshow S. In: John Wiley and Sons, Inc., ed. Applied Logistic Regression, 2nd edn. New York, USA: Wiley Series, Wiley-Interscience Publication, 2000.
  • 30
    Jones MP, Sloan SS, Rabine JC, Ebert CC, Huang CF, Kahrilas PJ. Hernia size is the dominant determinant of esophagitis presence and severity in gastroesophageal reflux disease. Am J Gastroenterol 2001; 96: 17117.
    Direct Link:
  • 31
    Avidan B, Sonnenberg A, Schnell TG, Chejfec G, Metz A, Sontag SJ. Hiatal hernia size, Barrett's length, and severity of acid reflux are all risk factors for esophageal adenocarcinoma. Am J Gastroenterol 2002; 97: 19306.
    Direct Link:
  • 32
    Sontag SJ, Schnell TG, Miller TO, et al. The importance of hiatal hernia in reflux esophagitis compared with lower esophageal sphincter pressure or smoking. J Clin Gastroenterol 1991; 13: 62843.
  • 33
    Jones MP, Sloan SS, Jovanovic B, Jovanovic B, Kahrilas PJ. Impaired egress rather than increased access: an important independent predictor of erosive oesophagitis. Neurogastroenterol Motil 2002; 14: 62531.
  • 34
    Fass R, Naliboff B, Higa L, et al. Differential effect of long term esophageal acid exposure on mechanosensitivity and chemosensitivity in humans. Gastroenterology 1998; 115: 136373.