These authors contributed equally to this study.
Clinical and endoscopic presentation of primary gastric lymphoma: a multicentre study
Article first published online: 27 FEB 2006
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 6, pages 721–726, March 2006
How to Cite
ANDRIANI, A., ZULLO, A., DI RAIMONDO, F., PATTI, C., TEDESCHI, L., RECINE, U., CARUSO, L., BONANNO, G., CHIARENZA, A., LIZZANI, G., MIEDICO, A., ROMANELLI, A., COSTA, A., LINEA, C., MARRONE, C., MIRTO, S., MISTRETTA, A., MONTALBANO, L., RESTIVO, G., VINCI, M., BIBAS, M., HASSAN, C., STELLA, F., COTTONE, M. and MORINI, S. (2006), Clinical and endoscopic presentation of primary gastric lymphoma: a multicentre study. Alimentary Pharmacology & Therapeutics, 23: 721–726. doi: 10.1111/j.1365-2036.2006.02826.x
- Issue published online: 27 FEB 2006
- Article first published online: 27 FEB 2006
- Publication data Submitted 21 November 2005 First decision 5 December 2005 Resubmitted 22 December 2005 Resubmitted 31 December 2005 Accepted 31 December 2005
Although the stomach is the most frequent site of intestinal lymphomas, few data are available on both clinical endoscopic presentation of gastric lymphoma and possible differences between low-grade and high-grade lymphomas.
Clinical, histological and endoscopic records of consecutive patients with primary low-grade or high-grade lymphoma diagnosed were retrieved. Symptoms were categorized as ‘alarm’ or ‘not alarm’. The endoscopic findings were classified as ‘normal’ or ‘abnormal’.
Overall, 144 patients with primary gastric lymphoma were detected, including 74 low-grade and 70 high-grade lymphoma. Alarm symptoms, particularly persistent vomiting and weight loss, were more frequently present in patients with high-grade lymphoma than in those with low-grade lymphoma (54% vs. 28%; P = 0.002). Low-grade lymphomas presented as ‘normal’ appearing mucosa (20% vs. 0%; P = 0.0004) or petechial haemorrhage in the fundus (9% vs. 0%; P = 0.02) more frequently than high-grade lymphomas, being also more often confined to the antrum (47% vs. 27%, P = 0.03) and associated with Helicobacter pylori infection (88% vs. 52%, P < 0.0001). On the contrary, high-grade lymphomas presented more commonly as ulcerative type (70% vs. 52%; P = 0.03), being also more frequently diagnosed in stage >I when compared with low-grade lymphomas (70% vs. 21%, P < 0.0001).
The overall prevalence of alarm symptoms is quite low and may be absent in more than 70% of patients with low-grade lymphoma.