RITMO group is composed of primary health care doctors interested in IBS management.
Predictive factors of irritable bowel syndrome improvement: 1-year prospective evaluation in 400 patients
Article first published online: 27 FEB 2006
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 6, pages 815–826, March 2006
How to Cite
MEARIN, F., BADÍA, X., BALBOA, A., BENAVENT, J., CABALLERO, A. M., DOMÍNGUEZ-MUÑOZ, E., GARRIGUES, V., PIQUÉ, J. M., ROSET, M., CUCALA, M., FIGUERAS, M. and FOR THE RITMO GROUP (2006), Predictive factors of irritable bowel syndrome improvement: 1-year prospective evaluation in 400 patients. Alimentary Pharmacology & Therapeutics, 23: 815–826. doi: 10.1111/j.1365-2036.2006.02828.x
- Issue published online: 27 FEB 2006
- Article first published online: 27 FEB 2006
- Publication data Submitted 25 July 2005 First decision 8 August 2005 Resubmitted 15 September 2005 Resubmitted 7 December 2005 Resubmitted 1 January 2006 Accepted 3 January 2006
The natural history of the irritable bowel syndrome is poorly understood.
To assess the clinical course of the irritable bowel syndrome and the factors that might predict it.
An observational prospective study, involving 400 irritable bowel syndrome patients meeting Rome II criteria. Symptoms were recorded in a diary over four non-consecutive months (1, 4, 7 and 10). Demographic data, associated disorders, psychological status and health-related quality of life were obtained.
At 1-year follow-up, half of the patients and half of their physicians considered irritable bowel syndrome to have improved, but improvement was minor. Diary data showed that, according to the type of symptom, improvement was small and quite different: diarrhoea in 19% of patients, abdominal pain frequency in 26%, constipation in 33% and abdominal pain intensity in 60%. Factors related to improvement at one year were: severe symptoms and poor health-related quality of life at first visit, irritable bowel syndrome-constipation, good improvement at 3 months, anxiety/depression, stress, symptoms related to meals and absence of comorbidity. By multivariate logistic regression, predictors were: severe basal symptoms and good improvement at 3 months (OR:CI 95%, 1.32:1.09–1.59 and 4.44:2.81–7.05).
At 1-year follow-up, half the patients and their physicians considered the irritable bowel syndrome to have had some improvement but, symptom diaries demonstrated that improvement was small and heterogeneous. Severe basal symptoms and improvement at 3 months were related to better prognosis.