Oats in the treatment of childhood coeliac disease: a 2-year controlled trial and a long-term clinical follow-up study
Article first published online: 28 APR 2006
Alimentary Pharmacology & Therapeutics
Volume 23, Issue 10, pages 1463–1472, May 2006
How to Cite
HOLM, K., MÄKI, M., VUOLTEENAHO, N., MUSTALAHTI, K., ASHORN, M., RUUSKA, T. and KAUKINEN, K. (2006), Oats in the treatment of childhood coeliac disease: a 2-year controlled trial and a long-term clinical follow-up study. Alimentary Pharmacology & Therapeutics, 23: 1463–1472. doi: 10.1111/j.1365-2036.2006.02908.x
- Issue published online: 28 APR 2006
- Article first published online: 28 APR 2006
- Publication data Submitted 27 July 2005 First decision 10 August 2005 Resubmitted 5 February 2006 Accepted 25 February 2006
The exclusion of oats from the diet in coeliac disease is controversial.
To study the long-term safety of oats in the treatment of children with coeliac disease.
Altogether 32 children with coeliac disease were enrolled in a 2-year controlled trial. Twenty-three children in remission were randomized either to oats or gluten challenge; when small bowel histological relapse was evident after gluten challenge, a gluten-free diet including oats was started. Furthermore, nine newly detected coeliac patients adopted an oat-containing gluten-free diet. Small bowel mucosal morphology, CD3+, αβ+ and γδ+ intraepithelial lymphocytes, human leucocyte antigen (HLA) DR expression and coeliac serology were determined. After the trial, the children were allowed to eat oats freely; follow-up was extended up to 7 years.
In coeliac children in remission, oats had no detrimental effect on intestinal histology or serology during the 2-year trial. In contrast, the gluten-challenge group relapsed after 3–12 months. Complete recovery from the disease was accomplished in all relapsed and newly detected patients on an oat-containing gluten-free diet. After the trial, 86% of the children preferred to consume oats and they all remained in remission.
In most children with coeliac disease, long-term consumption of oats is well tolerated, and it does not result in small bowel mucosal deterioration or immune activation.