Background and aim

Health-related quality of life of patients with chronic liver disease has been shown to be impaired in numerous studies. However, the factors which influence health-related quality of life in treated chronic liver patients are not quite known. This is the first study to assess the impact of physical and psychosocial determinants on a weighted score of health-related quality of life in patients with chronic liver disease.


The data of 1175 chronic liver patients were used to assess the relationship between items of the disease-specific Liver Disease Symptom Index 2.0 and the Short Form (SF)-6D weighted utility score by means of linear regression analyses.


Health-related quality of life was most strongly related to disease severity (B = −0.029) and joint pain (B = −0.023). Depression (B = −0.014), pain in the right upper abdomen (B = −0.014), decreased appetite (B =  0.014) and fatigue (B = −0.013) were also strongly related to health-related quality of life. In hepatitis C virus patients, disease severity (B = −0.037) and depression (B = −0.030) were strong determinants of health-related quality of life.


This study shows that health-related quality of life in chronic liver patients is clearly determined by disease severity, joint pain, depression, decreased appetite and fatigue. These patients may benefit most from interventions aimed at improving adaptation to the symptoms described.