Oesophageal acid exposure and altered neurocardiac function in patients with GERD and idiopathic cardiac dysrhythmias
Article first published online: 26 JUN 2006
Alimentary Pharmacology & Therapeutics
Volume 24, Issue 2, pages 361–370, July 2006
How to Cite
CUOMO, R., DE GIORGI, F., ADINOLFI, L., SARNELLI, G., LOFFREDO, F., EFFICIE, E., VERDE, C., SAVARESE, M. F., USAI, P. and BUDILLON, G. (2006), Oesophageal acid exposure and altered neurocardiac function in patients with GERD and idiopathic cardiac dysrhythmias. Alimentary Pharmacology & Therapeutics, 24: 361–370. doi: 10.1111/j.1365-2036.2006.02987.x
- Issue published online: 26 JUN 2006
- Article first published online: 26 JUN 2006
- Publication data Submitted 28 March 2006 First decision 12 April 2006 Resubmitted 9 May 2006 Accepted 10 May 2006
Oesophageal sensory stimuli alter neurocardiac function through autonomic reflexes.
To evaluate in patients with idiopathic supraventricular cardiac dysrhythmias and gastro-oesophageal reflux disease (GERD) whether GE reflux alters neurocardiac function and the effect of acid suppression on cardiac symptoms.
Thirty-two patients (13 females and 19 males; age: 20–69 years) with dysrhythmias plus GERD, and nine patients (five females and four males; age: 43–58 years) with GERD only, underwent simultaneous 24-h pH-metry and ECG monitoring. Power spectrum analysis of heart rate variability (PSHRV) was obtained with both its low frequency (LF, sympathetic modulation) and high frequency (HF, vagal modulation) components. Hourly mean oesophageal pH and LF/HF ratio were correlated. A 3 months full-dosage PPI therapy (esomeprazole 40 mg/day) was prescribed.
In 18 (56%) of the 32 patients with dysrhythmia and in none with GERD only, a significant (P < 0.05) correlation between oesophageal pH and LF/HF ratio (oesophagus–heart correlation) was observed. A significant reduction of cardiac symptoms after PPI therapy was observed only in these patients (13/16 vs. 4/11, P < 0.01).
This study has identified a subgroup of dysrhythmic patients in whom the oesophageal acid stimulus elicited cardiac autonomic reflexes. In these patients acid suppression seems to improve GERD and cardiac symptoms.