Review article: management of hepatic disease following haematopoietic cell transplant
Article first published online: 12 JUL 2006
Alimentary Pharmacology & Therapeutics
Volume 24, Issue 3, pages 441–452, August 2006
How to Cite
McDONALD, G. B. (2006), Review article: management of hepatic disease following haematopoietic cell transplant. Alimentary Pharmacology & Therapeutics, 24: 441–452. doi: 10.1111/j.1365-2036.2006.03001.x
- Issue published online: 12 JUL 2006
- Article first published online: 12 JUL 2006
- Publication data Submitted 2 May 2006 Accepted 16 May 2006
Hepatic diseases are common complications of haematopoietic cell transplant. The causes are multiple: myeloablative conditioning regimens may cause sinusoidal injury; acute and chronic graft-versus-host disease lead to damaged hepatocytes and small bile ducts; microcrystalline deposits in the gall bladder can cause biliary symptoms; drug-induced liver injury is common; and the liver may be infected by viruses and fungi during the period of severe immune suppression that follows transplant.
Pre-transplant evaluation and prevention of liver injury are often more useful than treatment of deeply jaundiced patients in improving transplant outcomes.
This review covers pre-transplant evaluation, common hepatobiliary problems in the six months following transplant, and hepatic problems in long-term survivors.