• 1
    D'Amico G, Morabito A, Pagliaro L, Marubini E, Liver Study Group of Cervello Hospital. Survival and prognostic indicators in compensated and decompensate cirrhosis. Dig Dis Sci 1986; 31: 46875.
  • 2
    Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology 1981; 80: 8009.
  • 3
    Pagliaro L, D'Amico G, Pasta L, et al. Portal hypertension in cirrhosis: natural history. In: BoschJ, GroszmannRJ, eds. Portal Hypertension. Pathophysiology and Treatment. Oxford: Blackwell, 1994: 7292.
  • 4
    Lebrec D, Stiegmann G. Prevention of recurrent variceal haemorrhage (secondary prophylaxis). Portal hypertension. In: RobertoDe Franchis, ed. Proceedings of the Third Baveno International Consensus Workshop. London: Blackwell Science, 2001: 1708.
  • 5
    D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 1995; 22: 33254.
  • 6
    Bosch J, Abraldes JG, Groszmann R. Current management of portal hypertension. J Hepatol 2003; 38: 5548.
  • 7
    Bernard B, Lebrec D, Mathurin P, Opolon P, Poynard T. Beta-adrenergic antagonist in the prevention of gastrointestinal rebleeding in patients with cirrhosis: a meta-analysis. Hepatology 1997; 25: 6370.
  • 8
    Bosch J, Mastai R, Kravetz D, et al. Effects of propranolol on azygos venous blood flow and hepatic and systemic homodynamic in cirrhosis. Hepatology 1984; 4: 12005.
  • 9
    Groszmann RJ, Bosch J, Grace ND, et al. Hemodynamic events in a prospective randomized trial of propanolol vs. placebo in the prevention of a first variceal hemorrhage. Gastroenterology 1990; 99: 14017.
  • 10
    Feu F, Gárcia-Págan JC, Luca A, Téres J, Bosch J, Ródes J. Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis. Lancet 1995; 346: 105659.
  • 11
    García-Tsao G, Grace N, Groszmann R, et al. Short-term effects of propanolol on portal venous pressure. Hepatology 1986; 6: 1016.
  • 12
    Gárcia-Págan JC, Feu F, Bosch J, Rodés J. Propanolol compared with propanolol plus isosorbide-5-mononitrate for portal hypertension in cirrhosis: a randomized controlled study. Ann Intern Med 1991; 114: 86973.
  • 13
    Merkel C, Sacerdoti D, Bolognesi M, et al. Hemodynamic evaluation of the addition of isosorbide-5-mononitrate to nadolol in cirrhotic patients with insufficient response to the beta-blocker alone. Hepatology 1997; 26: 3439.
  • 14
    Bureau C, Peron JM, Alric L, et al. ‘A la carte’ treatment of portal hypertension: adapting medical therapy to hemodynamic response for the prevention of bleeding. Hepatology 2002; 36: 13616.
  • 15
    Garcia-Págan JC, Navasa M, Bosch J, Bru C, Pizcueta P, Rodés J. Enhancement of portal pressure reduction by the association of isosorbide-5-mononitrate to propanolol administration in patients with cirrhosis. Hepatology 1990; 11: 2308.
  • 16
    Villanueva C, Balanzó J, Novella M, et al. Nadolol plus isosorbide mononitrate compared with sclerotherapy for the prevention of variceal rebleeding. New Engl J Med 1996; 20: 16249.
  • 17
    Gournay J, Masliha C, Martin T, Perrin D, Galmiche JP. Isosorbide mononitrate and propanolol compared with propranol alone for the prevention of variceal rebleeding. Hepatology 2000; 31: 123945.
  • 18
    De Franchis R, Primignani M. Endoscopic treatments for portal hypertension. Semin Liver Dis 1999; 19: 43955.
  • 19
    Laine L, El Newihi HM, Migikovsky B, Sloane R, Garcia F. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Ann Intern Med 1993; 119: 17.
  • 20
    De Franchis R. Updating consensus in portal hypertension: report of the Baveno III Consensus Workshop on Definitions, Methodology and Therapeutic Strategies in Portal Hypertension. J Hepatol 2000; 33: 84652.
  • 21
    Lo GH, Lai KH, Cheng JS, et al. The additive effect of sclerotherapy to patients receiving repeated endoscopic variceal ligation: a prospective, randomized trial. Hepatology 1998; 28: 3915.
  • 22
    Villanueva C, Minana J, Ortiz J, et al. Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med 2001; 345: 64755.
  • 23
    Lo G-H, Chen W-C, Chen M-H, et al. Banding ligation vs. nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding. Gastroenterology 2002; 123: 72834.
  • 24
    Patch D, Sabin CA, Goulis J, et al. A randomized, controlled trial of medical therapy vs. endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis. Gastroenterology 2002; 123: 10139.
  • 25
    Mela M, Thalheimer U, Burroughs A. Prevention of variceal rebleeding. Approach to management. MedGenMed 2003; 5: 9 (review).
  • 26
    Groszmann RJ, Garcia-Tsao G. Endoscopic variceal banding vs. pharmacological therapy for the prevention of recurrent variceal hemorrhage: what makes the difference? Gastroenterology 2002; 123: 138891.
  • 27
    Chalasani N, Kahi C, Francois F, et al. Improved patient survival after acute variceal bleeding: a multicenter, cohort study. Am J Gastroenterol 2003; 98: 6539.
    Direct Link:
  • 28
    Bosch J, Garcia-Pagan JC. Prevention of variceal rebleeding. Lancet 2003; 361: 9524.
  • 29
    Argonz J, Kravetz D, Suarez A, et al. Variceal band ligation and variceal band ligation plus sclerotherapy in the prevention of recurrent variceal bleeding in cirrhotic patients. A randomized, prospective and controlled trial. Gastrointest Endosc 2000; 51: 15763.
  • 30
    Hou MC, Lin HC, Kuo BI, Lee FY, Chang FY, Lee SD. The rebleeding course and long-term outcome of esophageal variceal hemorrhage after ligation: comparison with sclerotherapy. Scand J Gastroenterol 1999; 34: 10716.
  • 31
    Avgerinos A, Armonis A, Stefanidis G, et al. Sustained rise of portal pressure after sclerotherapy, but not band ligation, in acute variceal bleeding in cirrhosis. Hepatology 2004; 39: 162330.
  • 32
    Singh P, Pooran N, Indaram A, Bank S. Combined ligation and sclerotherapy vs. ligation alone for secondary prophylaxis of esophageal variceal bleeding: a meta-analysis. Am J Gastroenterol 2002; 97: 6239.
    Direct Link: