Rates and predictors of hepatitis C virus treatment in HCV–HIV-coinfected subjects
Article first published online: 25 JUL 2006
Alimentary Pharmacology & Therapeutics
Volume 24, Issue 4, pages 585–591, August 2006
How to Cite
BUTT, A. A., JUSTICE, A. C., SKANDERSON, M., GOOD, C. and KWOH, C. K. (2006), Rates and predictors of hepatitis C virus treatment in HCV–HIV-coinfected subjects. Alimentary Pharmacology & Therapeutics, 24: 585–591. doi: 10.1111/j.1365-2036.2006.03020.x
- Issue published online: 25 JUL 2006
- Article first published online: 25 JUL 2006
- Publication data Submitted 15 March 2006 First decision 27 April 2006 Resubmitted 9 May 2006 Accepted 30 May 2006
True treatment rates and the impact of comorbidities on treatment rates for hepatitis C virus in the HCV–HIV-coinfected subjects are unknown.
To quantify the rates of treatment prescription and the effect of comorbidities on hepatitis C virus treatment rates in HCV–HIV-coinfected veterans.
The Veterans Affairs National Patient Care Database was used to identify all hepatitis C virus-infected subjects between 1999 and 2003 using ICD-9 codes. Demographics, comorbidities and pharmacy data were retrieved. We used logistic regression to compare the predictors of hepatitis C virus treatment in hepatitis C virus-monoinfected and HCV–HIV-coinfected subjects.
We identified 120 507 hepatitis C virus-infected subjects, of which 6502 were HIV coinfected. 12% of the hepatitis C virus-monoinfected and 7% of the -coinfected subjects were prescribed hepatitis C virus treatment (P < 0.0001). Those not prescribed treatment were older (48.6 years vs. 47.7 years, P = 0.007) and more likely to be black (52% vs. 32%, P < 0.0001). HIV coinfected was less likely to be prescribed hepatitis C virus treatment (OR 0.74, 95% CI: 0.67–0.82). Among the coinfected subjects, the following were associated with non-treatment (OR, 95% CI): black race (0.45, 0.35–0.57); Hispanic race (0.56, 0.38–0.82); drug use (0.68, 0.53–0.88); anaemia (0.17, 0.11–0.26); bipolar disorder (0.63, 0.40–0.99); major depression (0.72, 0.53–0.99); mild depression (0.47, 0.35–0.62).
A small number of HCV–HIV-coinfected veterans are prescribed treatment for hepatitis C virus. Non-treatment is associated with increasing age, minority race, drug use and psychiatric illness. Further studies are needed to determine the eligibility for treatment and reasons for non-treatment for hepatitis C virus.