Influence of delaying gastric emptying on meal-related symptoms in healthy subjects
Article first published online: 12 SEP 2006
Alimentary Pharmacology & Therapeutics
Volume 24, Issue 7, pages 1045–1050, October 2006
How to Cite
TACK, J., COULIE, B., VERBEKE, K. and JANSSENS, J. (2006), Influence of delaying gastric emptying on meal-related symptoms in healthy subjects. Alimentary Pharmacology & Therapeutics, 24: 1045–1050. doi: 10.1111/j.1365-2036.2006.03095.x
- Issue published online: 12 SEP 2006
- Article first published online: 12 SEP 2006
- Publication data Submitted 18 December 2005 First decision 10 January 2006 Resubmitted 2 July 2006 Accepted 15 July 2006
Background Although delayed gastric emptying is often found in functional dyspepsia, a causal role for delayed emptying in inducing symptoms has not been demonstrated.
Aim To investigate the influence of delaying gastric emptying rate in healthy volunteers on the occurrence of meal-related symptoms.
Methods Fourteen healthy subjects (six men, mean age 23 ± 1) underwent gastric emptying studies twice using the 14C octanoic acid and 13C glycin breath test after pre-treatment with saline or sumatriptan 6 mg s.c. Breath samples were taken before meal and at 15-min intervals for a period of 360 min postprandially. At each breath sampling, the subject was asked to grade the intensity (0–6) of four dyspeptic symptoms.
Results Sumatriptan pre-treatment significantly delayed solid but not liquid gastric emptying (t1/2 respectively 159 ± 11 vs. 112 ± 9 min, P < 0.005 and 134 ± 11 vs. 116 ± 12 min, N.S.). Sumatriptan significantly decreased the mean cumulative symptom score (21.3 ± 5.5 vs. 8.0 ± 2.6, P = 0.01), as well as scores for each individual symptom.
Conclusion A moderate delay in gastric emptying in health is not associated with an increase of meal-related symptoms. This observation argues against a causal role for delayed gastric emptying in the pathogenesis of dyspeptic symptoms.