Effect of a proton pump inhibitor on postprandial gastric volume, emptying and symptoms in healthy human subjects: a pilot study
Article first published online: 12 SEP 2006
Alimentary Pharmacology & Therapeutics
Volume 24, Issue 7, pages 1037–1043, October 2006
How to Cite
GRUDELL, A. B. M., CAMILLERI, M., BURTON, D. D. and STEPHENS, D. A. (2006), Effect of a proton pump inhibitor on postprandial gastric volume, emptying and symptoms in healthy human subjects: a pilot study. Alimentary Pharmacology & Therapeutics, 24: 1037–1043. doi: 10.1111/j.1365-2036.2006.03102.x
- Issue published online: 12 SEP 2006
- Article first published online: 12 SEP 2006
- Publication data Submitted 16 June 2006 First decision 26 June 2006 Resubmitted 30 June 2006 Resubmitted 7 July 2006 Resubmitted 28 July 2006 Accepted 28 July 2006
Background In consensus guidelines, proton pump inhibitors (PPIs) are recommended for the treatment of functional dyspepsia. It is unclear whether PPIs change gastric volume or emptying.
Aim To assess the effect of a PPI, rabeprazole, on gastric volume and emptying and postprandial symptoms.
Methods In a double-blind, parallel-group placebo-controlled trial, 13 healthy participants were randomized to rabeprazole, 20 mg b.d., or placebo. On day 3, fasting gastric volume was measured using intravenous 99mTc-pertechnate and single photon emission computed tomography (SPECT). After the last dose of study medication, an 111In-chloride egg meal (300 kcal) was ingested, and postprandial gastric volume and emptying were measured by SPECT. Symptom ratings using a visual analogue scale (fullness, nausea, bloating, abdominal pain, aggregate score) were obtained at baseline and 15, 30, 45, 60 and 75 min postprandially. Group comparisons were performed using Mann–Whitney rank sum test.
Results There were no statistically significant differences in gastric volume or emptying in the two groups. However, there was a borderline increase in gastric volume with rabeprazole compared with placebo. Rabeprazole treatment reduced aggregate postprandial symptoms, particularly fullness, 30 min after the meal (P = 0.01).
Conclusions In healthy participants, rabeprazole, 20 mg b.d., did not significantly change gastric emptying, but reduced symptoms and had a borderline effect on gastric volume postprandially. The mechanism of reduced postprandial symptoms with a PPI requires further study.